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CRMP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646181

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CRMP1, Polyclonal Antibody
Full Product Name
CRMP1, NT (CRMP1, DPYSL1, ULIP3, Dihydropyrimidinase-related protein 1, Collapsin response mediator protein 1, Unc-33-like phosphoprotein 3)
Product Gene Name
anti-CRMP1 antibody
Product Synonym Names
Anti -CRMP1, NT (CRMP1, DPYSL1, ULIP3, Dihydropyrimidinase-related protein 1, Collapsin response mediator protein 1, Unc-33-like phosphoprotein 3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
62,184 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (5822491..5894785, complement). Location: 4p16.1
OMIM
602462
3D Structure
ModBase 3D Structure for Q14194
Immunogen
CRMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human CRMP1.

Product Categories/Family for anti-CRMP1 antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-CRMP1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CRMP1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-CRMP1 antibody

CRMP1 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CRMP1 antibody detected the CRMP1 protein (arrow).
Rabbit Anti-CRMP1 Polyclonal Antibody – Cat# MBS646181

Immunohistochemistry (IHC) of anti-CRMP1 antibody

CRMP1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CRMP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CRMP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646181

Other Notes

Small volumes of anti-CRMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRMP1 purchase

MBS646181 is an antibody targeting CRMP1. Also known as CRMP1, NT (CRMP1, DPYSL1, ULIP3, Dihydropyrimidinase-related protein 1, Collapsin response mediator protein 1, Unc-33-like phosphoprotein 3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRMP1. It may not necessarily be applicable to this product.

NCBI GI #
39644816
NCBI GeneID
1400
NCBI Accession #
AAH07898.2
UniProt Primary Accession #
Q14194
UniProt Secondary Accession #
Q13024; Q4W5F1; Q96TC8; A0EJG6
UniProt Related Accession #
Q14194
NCBI Official Full Name
CRMP1 protein, partial
NCBI Official Synonym Full Names
collapsin response mediator protein 1
NCBI Official Symbol
CRMP1
NCBI Official Synonym Symbols
DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3
UniProt Protein Name
Dihydropyrimidinase-related protein 1
UniProt Synonym Protein Names
Collapsin response mediator protein 1; CRMP-1; Unc-33-like phosphoprotein 3
Protein Family
Dihydropyrimidinase-related protein
UniProt Gene Name
CRMP1
UniProt Synonym Gene Names
DPYSL1; ULIP3; DRP-1; CRMP-1; ULIP-3
UniProt Entry Name
DPYL1_HUMAN
NCBI Protein Information
dihydropyrimidinase-related protein 1; dihydropyrimidinase-like 1; unc-33-like phosphoprotein 3; dihydropyrimidinase related protein-1

UniProt Comments for CRMP1

Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. Ref.11 Ref.12

Subunit structure: Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1

By similarity. Ref.10

Subcellular location: Cytoplasm. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Cytoplasm › cytoskeleton › spindle. Note: Associated with centrosomes and the mitotic spindle during metaphase. Ref.11

Tissue specificity: Brain.

Sequence similarities: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.
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Research Articles on CRMP1

1. CRMP1 is a novel candidate protein for schizophrenia traits

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRMP1 antibody

 Reference Product  PubMed Publications
 SEMA3A antibody  >13 publications with CRMP1 and SEMA3A
 CDK5 antibody  >6 publications with CRMP1 and CDK5
 PLXNA1 antibody  >2 publications with CRMP1 and PLXNA1
 PLXNA4 antibody  >1 publications with CRMP1 and PLXNA4
 PLXNA3 antibody  >1 publications with CRMP1 and PLXNA3
 FYN antibody  >1 publications with CRMP1 and FYN

Pathways associated with anti-CRMP1 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-CRMP1 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >4 publications with CRMP1 and Neoplasm Metastasis
 Inflammation Antibodies  >2 publications with CRMP1 and Inflammation
 Necrosis Antibodies  >2 publications with CRMP1 and Necrosis
 Pain Antibodies  >1 publications with CRMP1 and Pain
 Nerve Degeneration Antibodies  >1 publications with CRMP1 and Nerve Degeneration
 Liver Diseases Antibodies  >1 publications with CRMP1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with CRMP1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with CRMP1 and Liver Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with CRMP1 and Congenital Abnormalities

Organs/Tissues associated with anti-CRMP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >47 publications with CRMP1 and Nerve
 Brain Antibodies  >21 publications with CRMP1 and Brain
 Embryonic Tissue Antibodies  >8 publications with CRMP1 and Embryonic Tissue
 Lung Antibodies  >7 publications with CRMP1 and Lung
 Muscle Antibodies  >5 publications with CRMP1 and Muscle
 Heart Antibodies  >1 publications with CRMP1 and Heart
 Intestine Antibodies  >1 publications with CRMP1 and Intestine
 Testis Antibodies  >1 publications with CRMP1 and Testis
 Uncharacterized Tissue Antibodies  >1 publications with CRMP1 and Uncharacterized Tissue
 Eye Antibodies  >1 publications with CRMP1 and Eye
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