Rabbit Anti-MAN1A2 Polyclonal Antibody – Cat# MBS646186

Western Blot analysis of MAN1A2 expression in transfected 293T cell line by MAN1A2 polyclonal antibody. Lane 1: MAN1A2 transfected lysate (73kD). Lane 2: Non-transfected lysate.

MAN1A2 Antibody – Rabbit Polyclonal

Name: MAN1A2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646186
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646186

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2. More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAN1A2, Polyclonal Antibody

Full Product Name

MAN1A2 (Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, Mannosidase alpha Class 1A Member 2, Processing alpha-1,2-mannosidase IB, Alpha-1,2-mannosidase IB, MAN1B)

Product Gene Name

anti-MAN1A2 antibody

Product Synonym Names

Anti -MAN1A2 (Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, Mannosidase alpha Class 1A Member 2, Processing alpha-1,2-mannosidase IB, Alpha-1,2-mannosidase IB, MAN1B)

Immunogen Sequence

MTTPALLPLS GRRIPPLNLG PPSFPHHRAT LRLSEKFILL LILSAFITLC FGAFFFLPDS SKHKRFDLGL EDVLIPHVDA GKGAKNPGVF LIHGPDEHRH REEEERLRNK IRADHEKALE EAKEKLRKSR EEIRAEIQTE KNKVVQEMKI KENKPLPPVP IPNLVGIRGG DPEDNDIREK REKIKEMMKH AWDNYRTYGW GHNELRPIAR KGHSPNIFGS SQMGATIVDA LDTLYIMGLH DEFLDGQRWI EDNLDFSVNS EVSVFEVNIR FIGGLLAAYY LSGEEIFKIK AVQLAEKLLP AFNTPTGIPW AMVNLKSGVG RNWGWASAGS SILAEFGTLH MEFIHLSYLT GDLTYYKKVM HIRKLLQKMD RPNGLYPNYL NPRTGRWGQY HTSVGGLGDS FYEYLLKAWL MSDKTDHEAR KMYDDAIEAI EKHLIKKSRG GLTFIGEWKN GHLEKKMGHL ACFAGGMFAL GADGSRADKA GHYLELGAEI ARTCHESYDR TALKLGPESF KFDGAVEAVA VRQAEKYYIL RPEVIETYWY LWRFTHDPRY RQWGWEAALA IEKYCRVNGG FSGVKDVYSS TPTHDDVQQS FFLAETLKYL YLLFSGDDLL PLDHWVFNTE AHPLPVLHLA NTTLSGNPAV R

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human MAN1A2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

73,004 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (117910085..118068320). Location: 1p13

OMIM

604345

3D Structure

ModBase 3D Structure for O60476

Immunogen

Full length human MAN1A2, aa1-641 (NP_006690.1).

Product Categories/Family for anti-MAN1A2 antibody

Antibodies; Abs to Enzymes

Applications Tested/Suitable for anti-MAN1A2 antibody

Western Blot (WB)

Application Notes for anti-MAN1A2 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-MAN1A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAN1A2 purchase

MBS646186 is an antibody targeting MAN1A2. Also known as MAN1A2 (Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, Mannosidase alpha Class 1A Member 2, Processing alpha-1,2-mannosidase IB, Alpha-1,2-mannosidase IB, MAN1B). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAN1A2. It may not necessarily be applicable to this product.

NCBI GI #

17368019

NCBI GeneID

10905

NCBI Accession #

O60476.1

UniProt Primary Accession #

O60476

UniProt Secondary Accession #

Q9H510

UniProt Related Accession #

O60476

NCBI Official Full Name

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

NCBI Official Synonym Full Names

mannosidase, alpha, class 1A, member 2

NCBI Official Symbol

MAN1A2

NCBI Official Synonym Symbols

MAN1B

UniProt Protein Name

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

UniProt Synonym Protein Names

Mannosidase alpha class 1A member 2; Processing alpha-1,2-mannosidase IB

Protein Family

Mannosyl-oligosaccharide 1,2-alpha-mannosidase

UniProt Gene Name

MAN1A2

UniProt Synonym Gene Names

MAN1B; Alpha-1,2-mannosidase IB

UniProt Entry Name

MA1A2_HUMAN

NCBI Protein Information

mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; alpha1,2-mannosidase; alpha-1,2-mannosidase IB; processing alpha-1,2-mannosidase IB

NCBI Summary for MAN1A2

Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]

UniProt Comments for MAN1A2

Function: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2.

Catalytic activity: Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Cofactor: Calcium.

Enzyme regulation: Inhibited by both 1-deoxymannojirimycin and kifunensine.

Pathway: Protein modification; protein glycosylation.

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein.

Tissue specificity: Highest levels of expression in placenta and testis.

Sequence similarities: Belongs to the glycosyl hydrolase 47 family.

Research Articles on MAN1A2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MAN1A2 antibody

Products by Pathway	Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
N-Glycan Biosynthesis Pathway antibodies	N-Glycan Biosynthesis Pathway Diagram
N-Glycan Biosynthesis Pathway antibodies	N-Glycan Biosynthesis Pathway Diagram
N-glycan Precursor Trimming Pathway antibodies	N-glycan Precursor Trimming Pathway Diagram
N-glycan Precursor Trimming Pathway antibodies	N-glycan Precursor Trimming Pathway Diagram
N-glycan Trimming And Elongation In The Cis-Golgi Pathway antibodies	N-glycan Trimming And Elongation In The Cis-Golgi Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Progressive Trimming Of Alpha-1,2-linked Mannose Residues From Man9/8/7GlcNAc2 To Produce Man5GlcNAc2 Pathway antibodies	Progressive Trimming Of Alpha-1,2-linked Mannose Residues From Man9/8/7GlcNAc2 To Produce Man5GlcNAc2 Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-MAN1A2 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1 publications with MAN1A2 and Inflammation
Cardiovascular Diseases Antibodies	>1 publications with MAN1A2 and Cardiovascular Diseases
Necrosis Antibodies	>1 publications with MAN1A2 and Necrosis

Organs/Tissues associated with anti-MAN1A2 antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>1 publications with MAN1A2 and Vascular
Lung Antibodies	>1 publications with MAN1A2 and Lung