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SUGT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646310

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants… More details

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Product Overview

Online Datasheet in PDF
Product Name
SUGT1, Polyclonal Antibody
Full Product Name
SUGT1, CT (SUGT1, Suppressor of G2 allele of SKP1 homolog, Protein 40-6-3, Sgt1)
Product Gene Name
Product Synonym Names
Anti -SUGT1, CT (SUGT1, Suppressor of G2 allele of SKP1 homolog, Protein 40-6-3, Sgt1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
38,091 Da
Chromosome Location
Chromosome: 15; NC_005114.3 (65536894..65577747). Location: 15q12
3D Structure
ModBase 3D Structure for B0BN85
Immunogen
SUGT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 329-356 amino acids selected from the C-terminal region of human SUGT1.

Product Categories/Family for anti-Sugt1 antibody

Applications Tested/Suitable for anti-Sugt1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Sugt1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-Sugt1 antibody

SUGT1 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the SUGT1 antibody detected the SUGT1 protein (arrow).
Rabbit Anti-SUGT1 Polyclonal Antibody – Cat# MBS646310

Other Notes

Small volumes of anti-Sugt1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sugt1 purchase

MBS646310 is an antibody targeting Sugt1. Also known as SUGT1, CT (SUGT1, Suppressor of G2 allele of SKP1 homolog, Protein 40-6-3, Sgt1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Sugt1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
suppressor of G2 allele of SKP1 homolog
NCBI Official Synonym Full Names
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
NCBI Official Symbol
Sugt1
NCBI Official Synonym Symbols
Aa1114
UniProt Protein Name
Suppressor of G2 allele of SKP1 homolog
UniProt Gene Name
Sugt1
UniProt Entry Name
SUGT1_RAT
NCBI Protein Information
suppressor of G2 allele of SKP1 homolog

UniProt Comments for Sugt1

Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Subunit structure: Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90

By similarity.

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity. Note: Translocates the to nucleus upon heat shock, requiring S100A6

By similarity.

Domain: The CS domain mediates interaction with HSP90

By similarity.

Post-translational modification: Phosphorylated at Ser-252 and Ser-302, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex

By similarity.

Sequence similarities: Belongs to the SUGT1 family.Contains 1 CS domain.Contains 1 SGS domain.Contains 3 TPR repeats.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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