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ANXA7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6463208

MBS6463208 is an antibody targeting ANXA7. Also known as ANXA7, ID (Synexin, Annexin VII, Annexin-7, Annexin A7, ANX7, SNX, OK/SW-cl.95) (AP). Reactive in Human. Host: Rabbit. More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ANXA7, Polyclonal Antibody
Full Product Name
ANXA7, ID (Synexin, Annexin VII, Annexin-7, Annexin A7, ANX7, SNX, OK/SW-cl.95) (AP)
Product Gene Name
anti-ANXA7 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes human ANXA7
Preparation and Storage
May be stored at 4 degree C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
OMIM
186360
3D Structure
ModBase 3D Structure for P20073
Immunogen
KLH-conjugated synthetic peptide corresponding to a portion of amino acids within aa335-365 in the center region of human ANXA7
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-ANXA7 antibody

Antibodies; SNX (Sorting Nexin) Proteins
Applications Tested/Suitable for anti-ANXA7 antibody
Immunofluorescence (IF), ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-ANXA7 antibody
IF: 1:10-1:50
ELISA: 1:1,000
IHC: 1:50-1:100
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ANXA7 antibody

Western blot analysis of ANXA7 Antibody (Center) in A2058 cell line lysates (35ug/lane). ANXA7 (arrow) was detected using the purified Pab.
Rabbit Anti-ANXA7 Polyclonal Antibody – Cat# MBS6463208

Immunohistochemistry (IHC) of anti-ANXA7 antibody

(LEFT)Formalin-fixed and paraffin-embedded human brain tissue reacted with ANXA7 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.(RIGHT)Immunofluorescence analysis of ANXA7 Antibody (Center) with paraffin-embedded human brain tissue. 0.05 mg/ml primary antibody was followed by FITC-conjugated goat anti-rabbit lgG (whole molecule). FITC emits green fluorescence. Red counterstaining is PI.
Rabbit Anti-ANXA7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6463208

Flow Cytometry (FC/FACS) of anti-ANXA7 antibody

ANXA7 Antibody (Center) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ANXA7 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6463208

Product References and Citations for anti-ANXA7 antibody

1. Shirvan, A., et.al., Biochemistry 33(22), 6888-6901 (1994).

Other Notes

Small volumes of anti-ANXA7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA7. It may not necessarily be applicable to this product.

NCBI GI #
4502111
NCBI GeneID
310
NCBI Accession #
NP_001147.1
UniProt Primary Accession #
P20073
UniProt Secondary Accession #
Q5F2H3; Q5T0M6; Q5T0M7
UniProt Related Accession #
P20073
GenBank Nucleotide #
NM_001156.3
NCBI Official Full Name
annexin A7 isoform 1
NCBI Official Synonym Full Names
annexin A7
NCBI Official Symbol
ANXA7
NCBI Official Synonym Symbols
SNX; ANX7; SYNEXIN
UniProt Protein Name
Annexin A7
UniProt Synonym Protein Names
Annexin VII; Annexin-7; Synexin
Protein Family
Annexin
UniProt Gene Name
ANXA7
UniProt Synonym Gene Names
ANX7; SNX
UniProt Entry Name
ANXA7_HUMAN
NCBI Protein Information
annexin A7; annexin VII; annexin-7

NCBI Summary for ANXA7

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]
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UniProt Comments for ANXA7

ANXA7: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Interacts with PDCD6. Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. Belongs to the annexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding; Motility/polarity/chemotaxis; Lipid-binding

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane; nuclear envelope; cytosol; nucleus

Molecular Function: integrin binding; protein binding; calcium-dependent phospholipid binding; calcium ion binding; calcium-dependent protein binding

Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell proliferation; cellular water homeostasis; epithelial cell differentiation; hemostasis; autophagy; social behavior; response to calcium ion; response to organic cyclic substance; response to salt stress
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Research Articles on ANXA7

1. The role of distinct SGK1/FOXO3A-associated regulation in p53 versus ANXA7 responses were elucidated and proposed that aberrant SGK1 could affect reciprocal SGK1-FOXO3A-Akt regulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANXA7 antibody

 Reference Product  PubMed Publications
 LGALS3 antibody  >2 publications with ANXA7 and LGALS3
 SRI antibody  >1 publications with ANXA7 and SRI

Diseases associated with anti-ANXA7 antibody

 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >8 publications with ANXA7 and Liver Neoplasms
 Liver Diseases Antibodies  >7 publications with ANXA7 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >6 publications with ANXA7 and Carcinoma, Hepatocellular
 Genital Diseases, Male Antibodies  >6 publications with ANXA7 and Genital Diseases, Male
 Disease Models, Animal Antibodies  >5 publications with ANXA7 and Disease Models, Animal
 Nervous System Diseases Antibodies  >5 publications with ANXA7 and Nervous System Diseases
 Liver Neoplasms, Experimental Antibodies  >2 publications with ANXA7 and Liver Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >2 publications with ANXA7 and Cell Transformation, Neoplastic
 Poisoning Antibodies  >1 publications with ANXA7 and Poisoning
 Anemia Antibodies  >1 publications with ANXA7 and Anemia

Organs/Tissues associated with anti-ANXA7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with ANXA7 and Brain
 Liver Antibodies  >8 publications with ANXA7 and Liver
 Prostate Antibodies  >7 publications with ANXA7 and Prostate
 Vascular Antibodies  >7 publications with ANXA7 and Vascular
 Lymph Antibodies  >6 publications with ANXA7 and Lymph
 Lymph Node Antibodies  >6 publications with ANXA7 and Lymph Node
 Blood Antibodies  >5 publications with ANXA7 and Blood
 Muscle Antibodies  >5 publications with ANXA7 and Muscle
 Heart Antibodies  >4 publications with ANXA7 and Heart
 Embryonic Tissue Antibodies  >2 publications with ANXA7 and Embryonic Tissue
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