Rabbit Anti-GABRB2 Polyclonal Antibody – Cat# MBS646346

GABRB2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GABRB2 antibody detected the GABRB2 protein (arrow).

GABRB2 Antibody – Rabbit Polyclonal

Name: GABRB2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646346
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646346

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GABRB2, Polyclonal Antibody

Full Product Name

GABRB2, CT (GABRB2, Gamma-aminobutyric acid receptor subunit beta-2, GABA(A) receptor subunit beta-2)

Product Gene Name

anti-GABRB2 antibody

Product Synonym Names

Anti -GABRB2, CT (GABRB2, Gamma-aminobutyric acid receptor subunit beta-2, GABA(A) receptor subunit beta-2)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

59,150 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (160715426..160975130, complement). Location: 5q34

OMIM

600232

3D Structure

ModBase 3D Structure for P47870

Immunogen

GABRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-374 amino acids from the C-terminal region of human GABRB2.

Product Categories/Family for anti-GABRB2 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-GABRB2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-GABRB2 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-GABRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GABRB2 purchase

MBS646346 is an antibody targeting GABRB2. Also known as GABRB2, CT (GABRB2, Gamma-aminobutyric acid receptor subunit beta-2, GABA(A) receptor subunit beta-2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GABRB2. It may not necessarily be applicable to this product.

NCBI GI #

12548785

NCBI GeneID

2561

NCBI Accession #

NP_068711.1

UniProt Primary Accession #

P47870

UniProt Secondary Accession #

Q16323; Q4FZB2; A8K115; A8K1A0; D1LYT0; D1LYT1

UniProt Related Accession #

P47870

GenBank Nucleotide #

NM_021911.2

NCBI Official Full Name

gamma-aminobutyric acid receptor subunit beta-2 isoform 1

NCBI Official Synonym Full Names

gamma-aminobutyric acid (GABA) A receptor, beta 2

NCBI Official Symbol

GABRB2

UniProt Protein Name

Gamma-aminobutyric acid receptor subunit beta-2

UniProt Synonym Protein Names

GABA(A) receptor subunit beta-2

Protein Family

Gamma-aminobutyric acid receptor

UniProt Gene Name

GABRB2

UniProt Entry Name

GBRB2_HUMAN

NCBI Protein Information

gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor, beta 2; GABA(A) receptor subunit beta-2; gamma-aminobutyric acid A receptor beta 2

UniProt Comments for GABRB2

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents

By similarity.

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Tissue specificity: Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. Ref.3 Ref.7

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. [View classification]

Research Articles on GABRB2

1. Report additive inhibition of human alpha1beta2gamma2 GABAA receptors by mixtures of commonly used drugs of abuse.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GABRB2 antibody

Reference Product	PubMed Publications
GABRA1 antibody	>53 publications with GABRB2 and GABRA1
GABRG2 antibody	>43 publications with GABRB2 and GABRG2
GABRA6 antibody	>16 publications with GABRB2 and GABRA6
GABRA2 antibody	>9 publications with GABRB2 and GABRA2
GABRB1 antibody	>8 publications with GABRB2 and GABRB1
GABRA5 antibody	>7 publications with GABRB2 and GABRA5
GABRA4 antibody	>7 publications with GABRB2 and GABRA4
GABRG3 antibody	>4 publications with GABRB2 and GABRG3
GABRA3 antibody	>2 publications with GABRB2 and GABRA3

Pathways associated with anti-GABRB2 antibody

Products by Pathway	Pathway Diagram
GABA A Receptor Activation Pathway antibodies	GABA A Receptor Activation Pathway Diagram
GABA Receptor Activation Pathway antibodies	GABA Receptor Activation Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Ligand-gated Ion Channel Transport Pathway antibodies	Ligand-gated Ion Channel Transport Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GABRB2 antibody

Disease Name	Pubmed Publications
Schizophrenia Antibodies	>25 publications with GABRB2 and Schizophrenia
Nervous System Diseases Antibodies	>13 publications with GABRB2 and Nervous System Diseases
Central Nervous System Diseases Antibodies	>13 publications with GABRB2 and Central Nervous System Diseases
Brain Diseases Antibodies	>11 publications with GABRB2 and Brain Diseases
Seizures Antibodies	>11 publications with GABRB2 and Seizures
Epilepsy Antibodies	>10 publications with GABRB2 and Epilepsy
Substance-Related Disorders Antibodies	>8 publications with GABRB2 and Substance-Related Disorders
Disease Models, Animal Antibodies	>4 publications with GABRB2 and Disease Models, Animal
Inflammation Antibodies	>2 publications with GABRB2 and Inflammation
Ataxia Antibodies	>2 publications with GABRB2 and Ataxia

Organs/Tissues associated with anti-GABRB2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>48 publications with GABRB2 and Brain
Kidney Antibodies	>12 publications with GABRB2 and Kidney
Muscle Antibodies	>2 publications with GABRB2 and Muscle
Eye Antibodies	>2 publications with GABRB2 and Eye
Intestine Antibodies	>2 publications with GABRB2 and Intestine
Blood Antibodies	>1 publications with GABRB2 and Blood