Rabbit Anti-FMNL2 Polyclonal Antibody – Cat# MBS646359

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with FMNL2 antibody at 5-10ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.

Formin-Like Protein 2 (FMNL2) Antibody – Rabbit Polyclonal

Name: FMNL2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646359
Price: 785 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646359

Formin-like protein 2 is a cytoplasmic phosphoprotein belonging to the formin homology domain containing protein family and has a DAD (diaphanous autoregulatory domain), FH2 (formin homology 2) domain, and GBD/FH3 (Rho GTPase-binding/formin homology 3)… More details

$785 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Formin-like Protein 2 (FMNL2), Polyclonal Antibody

Full Product Name

Formin-like Protein 2 (FMNL2, Formin Homology 2 Domain-containing Protein 2, FHOD2, FLJ37546, KIAA1902)

Product Gene Name

anti-FMNL2 antibody

Product Synonym Names

Anti -Formin-like Protein 2 (FMNL2, Formin Homology 2 Domain-containing Protein 2, FHOD2, FLJ37546, KIAA1902)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human FMNL2. Species sequence homology: Bovine, chimpanzee, monkey, mouse and rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

123,321 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (153191684..153506348). Location: 2q23.3

3D Structure

ModBase 3D Structure for Q96PY5

Immunogen

Synthetic peptide corresponding to aa1-50 from human FMNL2 (KLH).

Product Categories/Family for anti-FMNL2 antibody

Antibodies; Abs to Actin Related Proteins

Applications Tested/Suitable for anti-FMNL2 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-FMNL2 antibody

Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1-3ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5-10ug/ml

Other Notes

Small volumes of anti-FMNL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FMNL2 purchase

MBS646359 is an antibody targeting FMNL2. Also known as Formin-like Protein 2 (FMNL2, Formin Homology 2 Domain-containing Protein 2, FHOD2, FLJ37546, KIAA1902). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FMNL2. It may not necessarily be applicable to this product.

NCBI GI #

52485606

NCBI GeneID

114793

NCBI Accession #

NP_443137.2

UniProt Primary Accession #

Q96PY5

UniProt Secondary Accession #

Q14CC9; Q4ZG52; Q8N3E0; B2RZH5

UniProt Related Accession #

Q96PY5

GenBank Nucleotide #

NM_052905.3

NCBI Official Full Name

formin-like protein 2

NCBI Official Synonym Full Names

formin-like 2

NCBI Official Symbol

FMNL2

NCBI Official Synonym Symbols

FHOD2

UniProt Protein Name

Formin-like protein 2

UniProt Synonym Protein Names

Formin homology 2 domain-containing protein 2

Protein Family

Formin-like protein

UniProt Gene Name

FMNL2

UniProt Synonym Gene Names

FHOD2; KIAA1902

UniProt Entry Name

FMNL2_HUMAN

NCBI Protein Information

formin-like protein 2; formin homology 2 domain containing 2; formin homology 2 domain-containing protein 2

NCBI Summary for FMNL2

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

UniProt Comments for FMNL2

Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. Ref.10

Subcellular location: Cytoplasm

By similarity.

Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments

By similarity.

Sequence similarities: Belongs to the formin homology family.Contains 1 DAD (diaphanous autoregulatory) domain.Contains 1 FH2 (formin homology 2) domain.Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.

Sequence caution: The sequence AAI13879.1 differs from that shown. Reason: Aberrant splicing.The sequence AAI14439.1 differs from that shown. Reason: Aberrant splicing.The sequence AAX88959.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAB67795.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on FMNL2

1. miR-137, induced by its upstream transcription factor HMGA1, can suppress colorectal cancer cell invasion and metastasis by targeting FMNL2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FMNL2 antibody

Reference Product	PubMed Publications
FMN2 antibody	>8 publications with FMNL2 and FMN2
TMEM30C antibody	>1 publications with FMNL2 and TMEM30C

Diseases associated with anti-FMNL2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>8 publications with FMNL2 and Neoplasms
Melanoma Antibodies	>3 publications with FMNL2 and Melanoma
Adenocarcinoma Antibodies	>2 publications with FMNL2 and Adenocarcinoma
Liver Neoplasms Antibodies	>2 publications with FMNL2 and Liver Neoplasms
Cerebral Infarction Antibodies	>1 publications with FMNL2 and Cerebral Infarction
Liver Cirrhosis Antibodies	>1 publications with FMNL2 and Liver Cirrhosis
Neoplasms, Experimental Antibodies	>1 publications with FMNL2 and Neoplasms, Experimental
Liver Diseases Antibodies	>1 publications with FMNL2 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with FMNL2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-FMNL2 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>3 publications with FMNL2 and Prostate
Lung Antibodies	>3 publications with FMNL2 and Lung
Brain Antibodies	>3 publications with FMNL2 and Brain
Kidney Antibodies	>2 publications with FMNL2 and Kidney
Liver Antibodies	>2 publications with FMNL2 and Liver
Vascular Antibodies	>2 publications with FMNL2 and Vascular
Lymph Node Antibodies	>2 publications with FMNL2 and Lymph Node
Placenta Antibodies	>2 publications with FMNL2 and Placenta
Eye Antibodies	>1 publications with FMNL2 and Eye
Testis Antibodies	>1 publications with FMNL2 and Testis