Rabbit Anti-FIGNL1 Polyclonal Antibody – Cat# MBS646391

FIGNL1 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the FIGNL1 antibody detected the FIGNL1 protein (arrow).

FIGNL1 Antibody – Rabbit Polyclonal

Name: FIGNL1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646391
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646391

FIGNL1 may regulate osteoblast proliferation and differentiation (By similarity). More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FIGNL1, Polyclonal Antibody

Full Product Name

FIGNL1, NT (FIGNL1, Fidgetin-like protein 1)

Product Gene Name

anti-FIGNL1 antibody

Product Synonym Names

Anti -FIGNL1, NT (FIGNL1, Fidgetin-like protein 1)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

74,077 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (50511827..50518088, complement). Location: 7p12.1

3D Structure

ModBase 3D Structure for Q6PIW4

Immunogen

FIGNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human FIGNL1.

Product Categories/Family for anti-FIGNL1 antibody

Antibodies; Abs to Proteins

Applications Tested/Suitable for anti-FIGNL1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-FIGNL1 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-FIGNL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FIGNL1 purchase

MBS646391 is an antibody targeting FIGNL1. Also known as FIGNL1, NT (FIGNL1, Fidgetin-like protein 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FIGNL1. It may not necessarily be applicable to this product.

NCBI GI #

112789543

NCBI GeneID

63979

NCBI Accession #

NP_001036227.1

UniProt Primary Accession #

Q6PIW4

UniProt Secondary Accession #

Q86V18; Q8ND59; Q9H8P1; Q9H917; D3DVM6

UniProt Related Accession #

Q6PIW4

GenBank Nucleotide #

NM_001042762.1

NCBI Official Full Name

fidgetin-like protein 1

NCBI Official Synonym Full Names

fidgetin-like 1

NCBI Official Symbol

FIGNL1

UniProt Protein Name

Fidgetin-like protein 1

Protein Family

Fidgetin-like protein

UniProt Gene Name

FIGNL1

UniProt Entry Name

FIGL1_HUMAN

NCBI Protein Information

fidgetin-like protein 1

UniProt Comments for FIGNL1

Function: Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. Ref.11

Catalytic activity: ATP + H2O = ADP + phosphate.

Cofactor: Magnesium

By similarity.

Subunit structure: Hexamer

By similarity. Interacts (via N-terminus one-half region) with RAD51; the interaction is direct. Interacts (via N-terminus one-half region) with SPIDR (via the C-terminus region); the interaction is direct. Ref.11

Subcellular location: Nucleus. Note: Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment. Ref.11

Domain: The N-terminus is necessary for its recruitment to DNA damage sites.

Sequence similarities: Belongs to the AAA ATPase family.

Sequence caution: The sequence BAB14567.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on FIGNL1

1. RAD51-binding protein fidgetin-like 1 (FIGNL1) is identified; FIGNL1 specifically interacts with RAD51 through its conserved RAD51 binding domain. Cells depleted of FIGNL1 show defective homologous recombination repair.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FIGNL1 antibody

Reference Product	PubMed Publications
FGF2 antibody	>1 publications with FIGNL1 and FGF2

Diseases associated with anti-FIGNL1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with FIGNL1 and Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with FIGNL1 and Neoplasms, Experimental
Breast Neoplasms Antibodies	>1 publications with FIGNL1 and Breast Neoplasms

Organs/Tissues associated with anti-FIGNL1 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>2 publications with FIGNL1 and Testis
Brain Antibodies	>2 publications with FIGNL1 and Brain
Bone Antibodies	>1 publications with FIGNL1 and Bone
Pancreas Antibodies	>1 publications with FIGNL1 and Pancreas
Thymus Antibodies	>1 publications with FIGNL1 and Thymus