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HIP1R Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646428

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases… More details

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Product Overview

Online Datasheet in PDF
Product Name
HIP1R, Polyclonal Antibody
Full Product Name
HIP1R (Huntingtin-interacting Protein 1-related Protein, HIP1-related Protein, Huntingtin-interacting Protein 12, HIP-12, HIP12, KIAA0655)
Product Gene Name
anti-HIP1R antibody
Product Synonym Names
Anti -HIP1R (Huntingtin-interacting Protein 1-related Protein, HIP1-related Protein, Huntingtin-interacting Protein 12, HIP-12, HIP12, KIAA0655)
Immunogen Sequence
MNSIKNVPAR VLSRRPGHSL EAEREQFDKT QAISISKAIN TQEAPVKEKH ARRIILGTHH EKGAFTFWSY AIGLPLPSSS ILSWKFCHVL HKVLRDGHPN VLHDCQRYRS NIREIGDLWG HLHDRYGQLV NVYTKLLLTK ISFHLKHPQF PAGLEVTDEV LEKAAGTDVN NIFQLTVEMF DYMDCELKLS ESVFRQLNTA IAVSQMSSGQ CRLAPLIQVI QDCSHLYHYT VKLLFKLHSC LPADTLQGHR DRFHEQFHSL RNFFRRASDM LYFKRLIQIP RLPEGPPNFL RASALAEHIK PVVVIPEEAP EDEEPENLIE ISTGPPAGEP VVVADLFDQT FGPPNGSVKD DRDLQIESLK REVEMLRSEL EKIKLEAQRY IAQLKSQVNA LEGELEEQRK QKQKALVDNE QLRHELAQLR AAQLEGERSQ GLREEAERKA SATEARYNKL KEKHSELVHV HAELLRKNAD TAKQLTVTQQ SQEEVARVKE QLAFQVEQVK RESELKLEEK SDQLEKLKRE LEAKAGELAR AQEALSHTEQ SKSELSSRLD TLSAEKDALS GAVRQREADL LAAQSLVRET EAALSREQQR SSQEQGELQG RLAERESQEQ GLRQRLLDEQ FAVLRGAAAE AAGILQDAVS KLDDPLHLRC TSSPDYLVSR AQEALDAVST LEEGHAQYLT SLADASALVA ALTRFSHLAA DTIINGGATS HLAPTDPADR LIDTCRECGA RALELMGQLQ DQQALRHMQA SLVRTPLQGI LQLGQELKPK SLDVRQEELG AVVDKEMAAT SAAIEDAVRR IEDMMNQARH ASSGVKLEVN ERILNSCTDL MKAIRLLVTT STSLQKEIVE SGRGAATQQE FYAKNSRWTE GLISASKAVG WGATQLVEAA DKVVLHTGKY EELIVCSHEI AASTAQLVAA SKVKANKHSP HLSRLQECSR TVNERAANVV ASTKSGQEQI EDRDTMDFSG LSLIKLKKQE METQVRVLEL EKTLEAERMR LGELRKQHYV LAGASGSPGE EVAIRPSTAP RSVTTKKPPL AQKPSVAPRQ DHQLDKKDGI YPAQLVNY
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human HIP1R. Species Crossreactivity: mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
119,388 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (123319045..123347508). Location: 12q24
OMIM
605613
3D Structure
ModBase 3D Structure for O75146
Immunogen
Full length human HIP1R, aa1-1068 (NP_003950.1).

Product Categories/Family for anti-HIP1R antibody

Antibodies; Abs to Disease Markers
Applications Tested/Suitable for anti-HIP1R antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-HIP1R antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Immunofluorescence (IF) of anti-HIP1R antibody

Immunofluorescence of purified antibody to HIP1R on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-HIP1R Polyclonal Antibody – Cat# MBS646428

Western Blot (WB) of anti-HIP1R antibody

Western Blot analysis of HIP1R expression in transfected 293T cell line by HIP1R polyclonal antibody. Lane 1: HIP1R transfected lysate (117.48kD). Lane 2: Non-transfected lysate.
Mouse Anti-HIP1R Polyclonal Antibody, Western Blot (WB) – Cat# MBS646428

Western Blot (WB) of anti-HIP1R antibody

HIP1R polyclonal antibody. Western Blot analysis of HIP1R expression in NIH/3T3.
Mouse Anti-HIP1R Polyclonal Antibody, Western Blot (WB) – Cat# MBS646428

Western Blot (WB) of anti-HIP1R antibody

HIP1R polyclonal antibody. Western Blot analysis of HIP1R expression in PC-12.
Mouse Anti-HIP1R Polyclonal Antibody, Western Blot (WB) – Cat# MBS646428

Other Notes

Small volumes of anti-HIP1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HIP1R purchase

MBS646428 is an antibody targeting HIP1R. Also known as HIP1R (Huntingtin-interacting Protein 1-related Protein, HIP1-related Protein, Huntingtin-interacting Protein 12, HIP-12, HIP12, KIAA0655). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for HIP1R. It may not necessarily be applicable to this product.

NCBI GI #
48762942
NCBI GeneID
9026
NCBI Accession #
NP_003950.1
UniProt Primary Accession #
O75146
UniProt Secondary Accession #
Q9UED9; A6NHQ6
UniProt Related Accession #
O75146
GenBank Nucleotide #
NM_003959.1
NCBI Official Full Name
huntingtin-interacting protein 1-related protein
NCBI Official Synonym Full Names
huntingtin interacting protein 1 related
NCBI Official Symbol
HIP1R
NCBI Official Synonym Symbols
HIP3; HIP12; ILWEQ
UniProt Protein Name
Huntingtin-interacting protein 1-related protein
UniProt Synonym Protein Names
Huntingtin-interacting protein 12
Protein Family
Huntingtin-interacting protein 1-related protein
UniProt Gene Name
HIP1R
UniProt Synonym Gene Names
HIP12; KIAA0655; HIP1-related protein; HIP-12
UniProt Entry Name
HIP1R_HUMAN
NCBI Protein Information
huntingtin-interacting protein 1-related protein; HIP-12; HIP1-related protein; huntingtin interacting protein 12; huntingtin-interacting protein 12

UniProt Comments for HIP1R

Function: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. Ref.5 Ref.6

Subunit structure: Interacts with actin. Does not interact with huntingtin

By similarity. Interacts with CLTB and HIP1. Homodimer. Homodimerization promotes actin binding. Ref.5 Ref.7 Ref.11

Subcellular location: Cytoplasm › perinuclear region. Endomembrane system. Cytoplasmic vesicle › clathrin-coated vesicle membrane. Note: Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region. Ref.5 Ref.6

Tissue specificity: Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.

Domain: Binds F-actin via the talin-like I/LWEQ domain.

Sequence similarities: Belongs to the SLA2 family.Contains 1 ENTH (epsin N-terminal homology) domain.Contains 1 I/LWEQ domain.

Sequence caution: The sequence BAA31630.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on HIP1R

1. HIP1r plays an important role in regulating the attachment of spindle microtubules to chromosomes during mitosis, an event that is required for accurate congression and segregation of chromosomes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HIP1R antibody

 Reference Product  PubMed Publications
 HIP1 antibody  >22 publications with HIP1R and HIP1
 SLA2 antibody  >12 publications with HIP1R and SLA2
 HTT antibody  >3 publications with HIP1R and HTT
 CTTN antibody  >2 publications with HIP1R and CTTN
 SH3KBP1 antibody  >1 publications with HIP1R and SH3KBP1

Pathways associated with anti-HIP1R antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with anti-HIP1R antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with HIP1R and Nervous System Diseases
 Cognition Disorders Antibodies  >5 publications with HIP1R and Cognition Disorders
 Neoplasms Antibodies  >4 publications with HIP1R and Neoplasms
 Hypertrophy Antibodies  >3 publications with HIP1R and Hypertrophy
 Weight Loss Antibodies  >1 publications with HIP1R and Weight Loss
 Disease Models, Animal Antibodies  >1 publications with HIP1R and Disease Models, Animal
 Hyperplasia Antibodies  >1 publications with HIP1R and Hyperplasia
 Inflammation Antibodies  >1 publications with HIP1R and Inflammation
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