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IRAK1BP1 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646473

Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. More details

$880 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
IRAK1BP1, Polyclonal Antibody
Full Product Name
IRAK1BP1 (Interleukin-1 Receptor-associated Kinase 1-binding Protein 1, MGC138458, MGC138460)
Product Gene Name
anti-Irak1bp1 antibody
Product Synonym Names
Anti -IRAK1BP1 (Interleukin-1 Receptor-associated Kinase 1-binding Protein 1, MGC138458, MGC138460)
Immunogen Sequence
MSLQKTPPTR VFVELVPWAD RSRENNLASG RETLPGLRHP LSSTQAQTAT REVQVSGTSE VSAGPDRAQV VVRVSSTKEA AAEAKKSVCR RLDYITQSLQ QQGVQAENIT VTKDFRRVEN AYHMEAEVCI TFTEFGKMQN ICNFLVEKLD SSVVISPPQF YHTPGSVENL RRQACLVAVE NAWRKAQEVC NLVGQTLGKP LLIKEEETKE WEGQIDDHQS SRLSSSLTVQ QKIKSATIHA ASKVFITFEV KGKEKRKKHL
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human IRAK1BP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
28,861 Da
Chromosome Location
Chromosome: 9; NC_000075.6 (82829806..82847688). Location: 9 E2; 9
3D Structure
ModBase 3D Structure for Q9ESJ7
Immunogen
Full length human IRAK1BP1, aa1-260 (NP_001010844.1).

Product Categories/Family for anti-Irak1bp1 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-Irak1bp1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-Irak1bp1 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 20ug/ml

Western Blot (WB) of anti-Irak1bp1 antibody

Western Blot analysis of IRAK1BP1 expression in transfected 293T cell line by IRAK1BP1 polyclonal antibody. Lane 1: IRAK1BP1 transfected lysate (28.6kD). Lane 2: Non-transfected lysate.
Mouse Anti-IRAK1BP1 Polyclonal Antibody – Cat# MBS646473

Immunofluorescence (IF) of anti-Irak1bp1 antibody

Immunofluorescence of purified antibody to IRAK1BP1 on HeLa cell. [antibody concentration 20ug/ml].
Mouse Anti-IRAK1BP1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS646473

Other Notes

Small volumes of anti-Irak1bp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Irak1bp1 purchase

MBS646473 is an antibody targeting Irak1bp1. Also known as IRAK1BP1 (Interleukin-1 Receptor-associated Kinase 1-binding Protein 1, MGC138458, MGC138460). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Irak1bp1. It may not necessarily be applicable to this product.

NCBI GI #
269847804
NCBI GeneID
65099
NCBI Accession #
NP_001161712.1
UniProt Primary Accession #
Q9ESJ7
UniProt Secondary Accession #
Q8BT82; Q8C645; Q9CRM0; Q9CV21; Q9CX27; Q9JK12
UniProt Related Accession #
Q9ESJ7
GenBank Nucleotide #
NM_001168240.1
NCBI Official Full Name
interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 2
NCBI Official Synonym Full Names
interleukin-1 receptor-associated kinase 1 binding protein 1
NCBI Official Symbol
Irak1bp1
NCBI Official Synonym Symbols
Aabp3; Aip70; Simpl; AI851240; 4921528N06Rik
UniProt Protein Name
Interleukin-1 receptor-associated kinase 1-binding protein 1
UniProt Synonym Protein Names
ActA-binding protein 70; PLK-interacting protein; Signaling molecule that associates with the mouse pelle-like kinase
Protein Family
Interleukin-1 receptor-associated kinase 1-binding protein
UniProt Gene Name
Irak1bp1
UniProt Synonym Gene Names
Aip70; Simpl; IRAK1-binding protein 1; SIMPL
UniProt Entry Name
IKBP1_MOUSE
NCBI Protein Information
interleukin-1 receptor-associated kinase 1-binding protein 1; Acta binding protein 3; Acta-binding protein 70; Plk-interacting protein; signaling molecule that associates with the mouse pelle-like kinase

UniProt Comments for Irak1bp1

Function: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. Ref.1 Ref.5

Subunit structure: Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1. May interact with Listeria monocytogenes actA. Ref.1 Ref.4 Ref.5 Ref.6

Subcellular location: Cytoplasm. Nucleus Ref.5.

Tissue specificity: Expressed in testis, brain, kidney, liver and heart. Ref.1

Developmental stage: Expression peaks at E10. Ref.1

Domain: The intrinsically disordered region interacts with HSPA1 and HSPA8.

Post-translational modification: Phosphorylation at Ser-55, Ser-61 and/or Ser-63 is required for full activity. Phosphorylated on at least one of Ser-234, Thr-236, Ser-241 and Thr-246 upon TNF-alpha activation, which favors nuclear translocation. Ref.7

Sequence similarities: Belongs to the IRAK1BP1 family.

Sequence caution: The sequence BAB32019.1 differs from that shown. Reason: Erroneous initiation.
Show more

Research Articles on Irak1bp1

1. IRAK1BP1 functions through its effects on NF-kappaB as a molecular switch to bias innate immune pathways toward the resolution of inflammation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Irak1bp1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with Irak1bp1 and Inflammation
 Death Antibodies  >1 publications with Irak1bp1 and Death
 Necrosis Antibodies  >1 publications with Irak1bp1 and Necrosis

Organs/Tissues associated with anti-Irak1bp1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1 publications with Irak1bp1 and Bone Marrow
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