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HSP90AB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646480

HSPCB are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. This protein normally associate with other cochaperones and play important roles in folding newly… More details

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Product Overview

Online Datasheet in PDF
Product Name
HSP90AB1, Polyclonal Antibody
Full Product Name
HSP90AB1, CT (HSP90AB1, HSP90B, HSPC2, HSPCB, Heat shock protein HSP 90-beta, Heat shock 84kD)
Product Gene Name
anti-HSP90AB1 antibody
Product Synonym Names
Anti -HSP90AB1, CT (HSP90AB1, HSP90B, HSPC2, HSPCB, Heat shock protein HSP 90-beta, Heat shock 84kD)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
83,264 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (44213903..44221625). Location: 6p12
OMIM
140572
3D Structure
ModBase 3D Structure for P08238
Immunogen
HSP90AB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 695~724 amino acids from the C-terminal region of human HSP90AB1.

Product Categories/Family for anti-HSP90AB1 antibody

Antibodies; Abs to Heat Shock Proteins
Applications Tested/Suitable for anti-HSP90AB1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-HSP90AB1 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-HSP90AB1 antibody

Western blot analysis of HSP90AB1 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). HSP90AB1 (arrow) was detected using the purified Pab.
Rabbit Anti-HSP90AB1 Polyclonal Antibody – Cat# MBS646480

Immunohistochemistry (IHC) of anti-HSP90AB1 antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with HSP90AB1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-HSP90AB1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646480

Flow Cytometry (FC/FACS) of anti-HSP90AB1 antibody

HSP90AB1 Antibody (C-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-HSP90AB1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS646480

Other Notes

Small volumes of anti-HSP90AB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSP90AB1 purchase

MBS646480 is an antibody targeting HSP90AB1. Also known as HSP90AB1, CT (HSP90AB1, HSP90B, HSPC2, HSPCB, Heat shock protein HSP 90-beta, Heat shock 84kD). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSP90AB1. It may not necessarily be applicable to this product.

NCBI GI #
431822408
NCBI GeneID
3326
NCBI Accession #
NP_001258901.1
UniProt Primary Accession #
P08238
UniProt Secondary Accession #
Q5T9W7; Q9NQW0; Q9NTK6; B2R5P0
UniProt Related Accession #
P08238
GenBank Nucleotide #
NM_001271972.1
NCBI Official Full Name
heat shock protein HSP 90-beta isoform c
NCBI Official Synonym Full Names
heat shock protein 90kDa alpha (cytosolic), class B member 1
NCBI Official Symbol
HSP90AB1
NCBI Official Synonym Symbols
HSP84; HSPC2; HSPCB; D6S182; HSP90B
UniProt Protein Name
Heat shock protein HSP 90-beta
UniProt Synonym Protein Names
Heat shock 84 kDa
Protein Family
Heat shock cognate protein
UniProt Gene Name
HSP90AB1
UniProt Synonym Gene Names
HSP90B; HSPC2; HSPCB; HSP 90; HSP 84; HSP84
UniProt Entry Name
HS90B_HUMAN
NCBI Protein Information
heat shock protein HSP 90-beta; HSP90-beta; heat shock 84 kDa; heat shock 90kD protein 1, beta

NCBI Summary for HSP90AB1

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
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UniProt Comments for HSP90AB1

Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Ref.22 Ref.29

Subunit structure: Homodimer. Interacts with p53/TP53

By similarity. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7

By similarity. Interacts with FKBP4. Ref.17 Ref.22 Ref.25

Subcellular location: Cytoplasm. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.17 Ref.21

Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins

By similarity.

Post-translational modification: Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro). Ref.24ISGylated. Ref.18S-nitrosylated; negatively regulates the ATPase activity

Probable.

Sequence similarities: Belongs to the heat shock protein 90 family.

Sequence caution: The sequence AAD14062.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAB66478.1 differs from that shown. Reason: Frameshift at position 709.
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Research Articles on HSP90AB1

1. differences in expression caused by the -144 polymorphism in the HSP90beta promoter are associated with cellular inflammatory responses and the severity of organ injury

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSP90AB1 antibody

 Reference Product  PubMed Publications
 HSP90AA1 antibody  >8 publications with HSP90AB1 and HSP90AA1
 TSSK6 antibody  >1 publications with HSP90AB1 and TSSK6
 HSPD1 antibody  >1 publications with HSP90AB1 and HSPD1

Pathways associated with anti-HSP90AB1 antibody

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 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with anti-HSP90AB1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with HSP90AB1 and Inflammation
 Nervous System Diseases Antibodies  >5 publications with HSP90AB1 and Nervous System Diseases
 Ovarian Diseases Antibodies  >4 publications with HSP90AB1 and Ovarian Diseases
 Disease Models, Animal Antibodies  >3 publications with HSP90AB1 and Disease Models, Animal
 Liver Neoplasms Antibodies  >3 publications with HSP90AB1 and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with HSP90AB1 and Liver Diseases
 Lung Neoplasms Antibodies  >2 publications with HSP90AB1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSP90AB1 and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >2 publications with HSP90AB1 and Brain Diseases
 Infertility, Male Antibodies  >2 publications with HSP90AB1 and Infertility, Male

Organs/Tissues associated with anti-HSP90AB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with HSP90AB1 and Blood
 Brain Antibodies  >6 publications with HSP90AB1 and Brain
 Intestine Antibodies  >5 publications with HSP90AB1 and Intestine
 Lung Antibodies  >5 publications with HSP90AB1 and Lung
 Ovary Antibodies  >5 publications with HSP90AB1 and Ovary
 Kidney Antibodies  >3 publications with HSP90AB1 and Kidney
 Liver Antibodies  >3 publications with HSP90AB1 and Liver
 Bone Antibodies  >3 publications with HSP90AB1 and Bone
 Embryonic Tissue Antibodies  >3 publications with HSP90AB1 and Embryonic Tissue
 Connective Tissue Antibodies  >3 publications with HSP90AB1 and Connective Tissue
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