CAPN2 Antibody – Rabbit Polyclonal

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Catalytic activity: Broad endopeptidase specificity.

Cofactor: Binds 7 calcium ions

By similarity.

Enzyme regulation: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.

Subunit structure: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).

Subcellular location: Cytoplasm. Cell membrane. Note: Translocates to the plasma membrane upon Ca2+ binding.

Tissue specificity: Ubiquitous.

Sequence similarities: Belongs to the peptidase C2 family.Contains 1 calpain catalytic domain.Contains 3 EF-hand domains.

Sequence caution: The sequence AAH07686.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence AAH11828.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.