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PRKRIR Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646605

Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth. More details

$880 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRKRIR, Polyclonal Antibody
Full Product Name
PRKRIR (52 kDa Repressor of the Inhibitor of the Protein Kinase, p52rIPK, 58 kDa Interferon-induced Protein Kinase-interacting Protein, p58IPK-interacting Protein, Death-associated Protein 4, THAP Domain-containing Protein 0, DAP4, P52RIPK, THAP0, MGC1027
Product Gene Name
Product Synonym Names
Anti -PRKRIR (52 kDa Repressor of the Inhibitor of the Protein Kinase, p52rIPK, 58 kDa Interferon-induced Protein Kinase-interacting Protein, p58IPK-interacting Protein, Death-associated Protein 4, THAP Domain-containing Protein 0, DAP4, P52RIPK, THAP0, MGC1027
Immunogen Sequence
MGQLKFNTSE EHHADMYRSD LPNPDTLSAE LHCWRIKWKH RGKDIELPST IYEALHLPDI KFFPNVYALL KVLCILPVMK VENERYENGR KRLKAYLRNT LTDQRSSNLA LLNINFDIKH DLDLMVDTYI KLYTSKSELP TDNSETVENT
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human PRKRIR.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
87,704 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (76061004..76091880, complement). Location: 11q13.5
OMIM
607374
3D Structure
ModBase 3D Structure for O43422
Immunogen
Full length human PRKRIR, aa1-150 (AAH21992.1).
Applications Tested/Suitable for anti-PRKRIR antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-PRKRIR antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-PRKRIR antibody

PRKRIR polyclonal antibody. Western Blot analysis of PRKRIR expression in human colon.
Mouse Anti-PRKRIR Polyclonal Antibody – Cat# MBS646605

Western Blot (WB) of anti-PRKRIR antibody

Western Blot analysis of PRKRIR expression in transfected 293T cell line by PRKRIR polyclonal antibody. Lane 1: PRKRIR transfected lysate (16.5kD). Lane 2: Non-transfected lysate.
Mouse Anti-PRKRIR Polyclonal Antibody, Western Blot (WB) – Cat# MBS646605

Immunofluorescence (IF) of anti-PRKRIR antibody

Immunofluorescence of purified antibody to PRKRIR on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-PRKRIR Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS646605

Other Notes

Small volumes of anti-PRKRIR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRKRIR purchase

MBS646605 is an antibody targeting PRKRIR. Also known as PRKRIR (52 kDa Repressor of the Inhibitor of the Protein Kinase, p52rIPK, 58 kDa Interferon-induced Protein Kinase-interacting Protein, p58IPK-interacting Protein, Death-associated Protein 4, THAP Domain-containing Protein 0, DAP4, P52RIPK, THAP0, MGC1027. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKRIR. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
PRKRIR protein
NCBI Official Synonym Full Names
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
NCBI Official Symbol
PRKRIR
NCBI Official Synonym Symbols
DAP4; THAP0; THAP12; P52rIPK
UniProt Protein Name
52 kDa repressor of the inhibitor of the protein kinase
UniProt Synonym Protein Names
58 kDa interferon-induced protein kinase-interacting protein; p58IPK-interacting protein; Death-associated protein 4; THAP domain-containing protein 0
UniProt Gene Name
PRKRIR
UniProt Synonym Gene Names
DAP4; P52RIPK; THAP0; p52rIPK
UniProt Entry Name
P52K_HUMAN
NCBI Protein Information
52 kDa repressor of the inhibitor of the protein kinase; THAP domain containing 12; death-associated protein 4; p58IPK-interacting protein; inhibitor of protein kinase PKR; THAP domain-containing protein 0; 58 kDa interferon-induced protein kinase-interacting protein

UniProt Comments for PRKRIR

Function: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth.

Subunit structure: Interacts with P58IPK, probably sequestring it.

Sequence similarities: Contains 1 THAP-type zinc finger.

Sequence caution: The sequence AAH21992.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB43226.1 differs from that shown. Reason: Frameshift at position 471.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRKRIR antibody

Diseases associated with anti-PRKRIR antibody

Organs/Tissues associated with anti-PRKRIR antibody

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