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SLC23A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646609

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial… More details

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Product Overview

Online Datasheet in PDF
Product Name
SLC23A1, Polyclonal Antibody
Full Product Name
SLC23A1, NT (SLC23A1, SVCT1, YSPL3, Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, Yolk sac permease-like molecule 3)
Product Gene Name
anti-SLC23A1 antibody
Product Synonym Names
Anti -SLC23A1, NT (SLC23A1, SVCT1, YSPL3, Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, Yolk sac permease-like molecule 3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
64,831 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (138702885..138720632, complement). Location: 5q31.2
OMIM
603790
3D Structure
ModBase 3D Structure for Q9UHI7
Immunogen
SLC23A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC23A1.

Product Categories/Family for anti-SLC23A1 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-SLC23A1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SLC23A1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-SLC23A1 antibody

SLC23A1 Antibody (N-term) western blot analysis in HepG2(lane 1),NCI-H292(lane 2) cell line lysates (35ug/lane).This demonstrates the SLC23A1 antibody detected the SLC23A1 protein (arrow).
Rabbit Anti-SLC23A1 Polyclonal Antibody – Cat# MBS646609

Immunohistochemistry (IHC) of anti-SLC23A1 antibody

SLC23A1 Antibdy (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC23A1 Antibdy (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-SLC23A1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646609

Other Notes

Small volumes of anti-SLC23A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC23A1 purchase

MBS646609 is an antibody targeting SLC23A1. Also known as SLC23A1, NT (SLC23A1, SVCT1, YSPL3, Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, Yolk sac permease-like molecule 3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC23A1. It may not necessarily be applicable to this product.

NCBI GI #
44680145
NCBI GeneID
9963
NCBI Accession #
NP_005838.3
UniProt Primary Accession #
Q9UHI7
UniProt Secondary Accession #
O95191; Q8WWB6; Q9UGH4; Q9UI39
UniProt Related Accession #
Q9UHI7
GenBank Nucleotide #
NM_005847.4
NCBI Official Full Name
solute carrier family 23 member 1 isoform a
NCBI Official Synonym Full Names
solute carrier family 23 (ascorbic acid transporter), member 1
NCBI Official Symbol
SLC23A1
NCBI Official Synonym Symbols
SVCT1; YSPL3; SLC23A2
UniProt Protein Name
Solute carrier family 23 member 1
UniProt Synonym Protein Names
Na(+)/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1; hSVCT1; Yolk sac permease-like molecule 3
Protein Family
Solute carrier family
UniProt Gene Name
SLC23A1
UniProt Synonym Gene Names
SVCT1; YSPL3; hSVCT1
UniProt Entry Name
S23A1_HUMAN
NCBI Protein Information
solute carrier family 23 member 1; hSVCT1; yolk sac permease-like molecule 3; Na(+)/L-ascorbic acid transporter 1; sodium-dependent vitamin C transporter 1; sodium-dependent vitamin C transporter-1; solute carrier family 23 (nucleobase transporters), member 1; solute carrier family 23 (nucleobase transporters), member 2

NCBI Summary for SLC23A1

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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UniProt Comments for SLC23A1

Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

Subcellular location: Cell membrane; Multi-pass membrane protein Ref.9.

Tissue specificity: Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.

Post-translational modification: Phosphorylated

Probable.

Miscellaneous: Treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells.

Sequence similarities: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. [View classification]
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Research Articles on SLC23A1

1. SVCT1 directly interacts with GRHPR.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC23A1 antibody

 Reference Product  PubMed Publications
 SLC6A14 antibody  >1 publications with SLC23A1 and SLC6A14

Pathways associated with anti-SLC23A1 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Vitamin C (ascorbate) Metabolism Pathway antibodies  Vitamin C (ascorbate) Metabolism Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram

Diseases associated with anti-SLC23A1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with SLC23A1 and Neoplasms
 Brain Diseases Antibodies  >5 publications with SLC23A1 and Brain Diseases
 Kidney Diseases Antibodies  >4 publications with SLC23A1 and Kidney Diseases
 Nervous System Diseases Antibodies  >2 publications with SLC23A1 and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with SLC23A1 and Liver Diseases
 Cholestasis Antibodies  >2 publications with SLC23A1 and Cholestasis
 Lung Neoplasms Antibodies  >1 publications with SLC23A1 and Lung Neoplasms
 Liver Cirrhosis, Experimental Antibodies  >1 publications with SLC23A1 and Liver Cirrhosis, Experimental
 Cholestasis, Intrahepatic Antibodies  >1 publications with SLC23A1 and Cholestasis, Intrahepatic
 Liver Cirrhosis Antibodies  >1 publications with SLC23A1 and Liver Cirrhosis

Organs/Tissues associated with anti-SLC23A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >17 publications with SLC23A1 and Kidney
 Intestine Antibodies  >16 publications with SLC23A1 and Intestine
 Liver Antibodies  >14 publications with SLC23A1 and Liver
 Brain Antibodies  >11 publications with SLC23A1 and Brain
 Blood Antibodies  >7 publications with SLC23A1 and Blood
 Prostate Antibodies  >2 publications with SLC23A1 and Prostate
 Spleen Antibodies  >1 publications with SLC23A1 and Spleen
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