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CALD1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6466664

MBS6466664 is an antibody targeting CALD1. Also known as CALD1, ID (Caldesmon, CDM, CAD, CALD1) (MaxLight 550). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CALD1, Polyclonal Antibody
Full Product Name
CALD1, ID (Caldesmon, CDM, CAD, CALD1) (MaxLight 550)
Product Gene Name
anti-CALD1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human CALD1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
65,620 Da
OMIM
114213
3D Structure
ModBase 3D Structure for Q05682
Immunogen
KLH-conjugated synthetic peptide corresponding to a portion of amino acids within aa435-465 from the center region of human CALD1 (Accession #Q05682).
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-CALD1 antibody

Antibodies; Caldesmon
Applications Tested/Suitable for anti-CALD1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-CALD1 antibody
FC/FACS: 1:10-1:50
FLISA: 1:1000
IHC: 1:10-1:50
WB: 1:50-1:100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CALD1 antibody

Western blot analysis of CALD1 antibody (Center) in A2058 cell line lysates (35ug/lane). CALD1 (arrow) was detected using the purified Pab.
Rabbit Anti-CALD1 Polyclonal Antibody – Cat# MBS6466664

Immunohistochemistry (IHC) of anti-CALD1 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma with CALD1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CALD1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6466664

Flow Cytometry (FC/FACS) of anti-CALD1 antibody

Flow cytometric analysis of NCI-H292 cells using CALD1 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CALD1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6466664

Product References and Citations for anti-CALD1 antibody

1. Yoshio, T., FEBS Lett. 581(20), 3777-3782 (2007). 2. Mani, R.S., Biochemistry 31(47), 11896-11901 (1992).

Other Notes

Small volumes of anti-CALD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CALD1. It may not necessarily be applicable to this product.

NCBI GI #
4826657
NCBI GeneID
800
NCBI Accession #
NP_004333
UniProt Primary Accession #
Q05682
UniProt Secondary Accession #
Q13978; Q13979; Q14741; Q14742; Q9UD91; A8K0X1
UniProt Related Accession #
Q05682
GenBank Nucleotide #
NM_004342
NCBI Official Full Name
caldesmon isoform 2
NCBI Official Synonym Full Names
caldesmon 1
NCBI Official Symbol
CALD1
NCBI Official Synonym Symbols
CDM; HCAD; LCAD; H-CAD; L-CAD; NAG22
UniProt Protein Name
Caldesmon
Protein Family
Caldesmon
UniProt Gene Name
CALD1
UniProt Synonym Gene Names
CAD; CDM; CDM
UniProt Entry Name
CALD1_HUMAN
NCBI Protein Information
caldesmon

UniProt Comments for CALD1

Caldesmon: a cytoskeletal protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells. May act as a bridge between myosin and actin filaments. Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Five alternatively spliced isoforms have been described.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: cytoskeleton; myofibril; plasma membrane; actin cap; cytosol; actin cytoskeleton

Molecular Function: calmodulin binding; myosin binding; tropomyosin binding; actin binding

Biological Process: muscle contraction; cell motility
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CALD1 antibody

 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram

Diseases associated with anti-CALD1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with CALD1 and Neoplasms
 Nervous System Diseases Antibodies  >1 publications with CALD1 and Nervous System Diseases
 Movement Disorders Antibodies  >1 publications with CALD1 and Movement Disorders
 Neoplasms, Experimental Antibodies  >1 publications with CALD1 and Neoplasms, Experimental
 Urinary Bladder Neoplasms Antibodies  >1 publications with CALD1 and Urinary Bladder Neoplasms
 Inflammation Antibodies  >1 publications with CALD1 and Inflammation
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with CALD1 and Prenatal Exposure Delayed Effects
 Hyperplasia Antibodies  >1 publications with CALD1 and Hyperplasia

Organs/Tissues associated with anti-CALD1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >5 publications with CALD1 and Muscle
 Blood Antibodies  >3 publications with CALD1 and Blood
 Prostate Antibodies  >2 publications with CALD1 and Prostate
 Brain Antibodies  >2 publications with CALD1 and Brain
 Bladder Antibodies  >1 publications with CALD1 and Bladder
 Lung Antibodies  >1 publications with CALD1 and Lung
 Vascular Antibodies  >1 publications with CALD1 and Vascular
 Intestine Antibodies  >1 publications with CALD1 and Intestine
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