Rabbit Anti-ACVR2A Polyclonal Antibody – Cat# MBS646734

Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

ACVR2A Antibody – Rabbit Polyclonal

Name: ACVR2A Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646734
Price: 910 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646734

ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric… More details

$910 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACVR2A, Polyclonal Antibody

Full Product Name

ACVR2A, NT (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2)

Product Gene Name

anti-ACVR2A antibody

Product Synonym Names

Anti -ACVR2A, NT (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.09% sodium azide.

Purity/Purification

Purified
Purified by ammonium sulfate precipitation.

Specificity

Recognizes human ACVR2A.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

57,848 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (148602086..148688396). Location: 2q22.3

OMIM

102581

3D Structure

ModBase 3D Structure for P27037

Immunogen

Synthetic peptide corresponding to N-terminal region of human ACVR2A, conjugated to KLH.

Product Categories/Family for anti-ACVR2A antibody

Antibodies; Abs to Activin Receptors

Applications Tested/Suitable for anti-ACVR2A antibody

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-ACVR2A antibody

Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1:1000
Western Blot: 1:100-1:500
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Other Notes

Small volumes of anti-ACVR2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACVR2A purchase

MBS646734 is an antibody targeting ACVR2A. Also known as ACVR2A, NT (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACVR2A. It may not necessarily be applicable to this product.

NCBI GI #

518828583

NCBI GeneID

NCBI Accession #

NP_001265508.1

UniProt Primary Accession #

P27037

UniProt Secondary Accession #

Q53TH4; Q6NWV2; Q92474; B2RAB8; D3DP85

UniProt Related Accession #

P27037

GenBank Nucleotide #

NM_001278579.1

NCBI Official Full Name

activin receptor type-2A isoform 1

NCBI Official Synonym Full Names

activin A receptor, type IIA

NCBI Official Symbol

ACVR2A

NCBI Official Synonym Symbols

ACVR2; ACTRII

UniProt Protein Name

Activin receptor type-2A

UniProt Synonym Protein Names

Activin receptor type IIA

Protein Family

Activin receptor

UniProt Gene Name

ACVR2A

UniProt Synonym Gene Names

ACVR2; ACTR-IIA; ACTRIIA

UniProt Entry Name

AVR2A_HUMAN

NCBI Protein Information

activin receptor type-2A

NCBI Summary for ACVR2A

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

UniProt Comments for ACVR2A

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor: Magnesium or manganese

By similarity.

Subunit structure: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 protein kinase domain.

Research Articles on ACVR2A

1. ACVR2A was identified as a subnetwork component in functional association network analysis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACVR2A antibody

Reference Product	PubMed Publications
BMP7 antibody	>5 publications with ACVR2A and BMP7
BMP2 antibody	>4 publications with ACVR2A and BMP2
SMAD4 antibody	>1 publications with ACVR2A and SMAD4
INHA antibody	>1 publications with ACVR2A and INHA
INHBB antibody	>1 publications with ACVR2A and INHBB
ACVRL1 antibody	>1 publications with ACVR2A and ACVRL1
ACVR1B antibody	>1 publications with ACVR2A and ACVR1B

Pathways associated with anti-ACVR2A antibody

Products by Pathway	Pathway Diagram
ALK1 Signaling Events Pathway antibodies	ALK1 Signaling Events Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Regulation Of Signaling By NODAL Pathway antibodies	Regulation Of Signaling By NODAL Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By Activin Pathway antibodies	Signaling By Activin Pathway Diagram
Signaling By BMP Pathway antibodies	Signaling By BMP Pathway Diagram
Signaling By NODAL Pathway antibodies	Signaling By NODAL Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram

Diseases associated with anti-ACVR2A antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with ACVR2A and Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with ACVR2A and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>3 publications with ACVR2A and Congenital Abnormalities
Nervous System Diseases Antibodies	>2 publications with ACVR2A and Nervous System Diseases
Craniofacial Abnormalities Antibodies	>2 publications with ACVR2A and Craniofacial Abnormalities
Disease Models, Animal Antibodies	>2 publications with ACVR2A and Disease Models, Animal
Nervous System Malformations Antibodies	>1 publications with ACVR2A and Nervous System Malformations
Heart Defects, Congenital Antibodies	>1 publications with ACVR2A and Heart Defects, Congenital
Fibrosis Antibodies	>1 publications with ACVR2A and Fibrosis
Breast Neoplasms Antibodies	>1 publications with ACVR2A and Breast Neoplasms

Organs/Tissues associated with anti-ACVR2A antibody

Organ/Tissue Name	Pubmed Publications
Placenta Antibodies	>4 publications with ACVR2A and Placenta
Embryonic Tissue Antibodies	>3 publications with ACVR2A and Embryonic Tissue
Ovary Antibodies	>3 publications with ACVR2A and Ovary
Blood Antibodies	>3 publications with ACVR2A and Blood
Pancreas Antibodies	>2 publications with ACVR2A and Pancreas
Liver Antibodies	>1 publications with ACVR2A and Liver
Mammary Gland Antibodies	>1 publications with ACVR2A and Mammary Gland
Testis Antibodies	>1 publications with ACVR2A and Testis
Eye Antibodies	>1 publications with ACVR2A and Eye
Vascular Antibodies	>1 publications with ACVR2A and Vascular