Rabbit Anti-FNTA Polyclonal Antibody – Cat# MBS646741

Western blot analysis of FNTA (arrow) using rabbit polyclonal FNTA Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FNTA gene.

FNTA Antibody – Rabbit Polyclonal

Name: FNTA Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646741
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646741

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FNTA, Polyclonal Antibody

Full Product Name

FNTA, NT (FNTA, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, CAAX farnesyltransferase subunit alpha, FTase-alpha, Ras proteins prenyltransferase subunit alpha, Type I protein geranyl-geranyltransferase subunit alpha)

Product Gene Name

anti-FNTA antibody

Product Synonym Names

Anti -FNTA, NT (FNTA, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, CAAX farnesyltransferase subunit alpha, FTase-alpha, Ras proteins prenyltransferase subunit alpha, Type I protein geranyl-geranyltransferase subunit alpha)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

44,409 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (42911442..42940931). Location: 8p11

OMIM

134635

3D Structure

ModBase 3D Structure for P49354

Immunogen

FNTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-79 amino acids from the N-terminal region of human FNTA.

Product Categories/Family for anti-FNTA antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins

Applications Tested/Suitable for anti-FNTA antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-FNTA antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-FNTA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FNTA purchase

MBS646741 is an antibody targeting FNTA. Also known as FNTA, NT (FNTA, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, CAAX farnesyltransferase subunit alpha, FTase-alpha, Ras proteins prenyltransferase subunit alpha, Type I protein geranyl-geranyltransferase subunit alpha). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FNTA. It may not necessarily be applicable to this product.

NCBI GI #

34782840

NCBI GeneID

2339

NCBI Accession #

AAH17029.2

UniProt Primary Accession #

P49354

UniProt Secondary Accession #

Q53XJ9; Q9UDC1; A6NJW0

UniProt Related Accession #

P49354; AAB26814

NCBI Official Full Name

FNTA protein, partial

NCBI Official Synonym Full Names

farnesyltransferase, CAAX box, alpha

NCBI Official Symbol

FNTA

NCBI Official Synonym Symbols

FPTA; PTAR2; PGGT1A

UniProt Protein Name

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

UniProt Synonym Protein Names

CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha

Protein Family

Protein farnesyltransferase/geranylgeranyltransferase

UniProt Gene Name

FNTA

UniProt Synonym Gene Names

GGTase-I-alpha

UniProt Entry Name

FNTA_HUMAN

NCBI Protein Information

protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; FTase-alpha; GGTase-I-alpha; farnesyl-protein transferase alpha-subunit; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; protein prenyltransferase alpha subunit repeat containing 2

UniProt Comments for FNTA

Function: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK

By similarity.

Catalytic activity: Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Enzyme regulation: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK

By similarity.

Subunit structure: Heterodimer of an alpha and a beta subunit. Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA

By similarity. Ref.15 Ref.16 Ref.17

Post-translational modification: Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA

By similarity.

Sequence similarities: Belongs to the protein prenyltransferase subunit alpha family.Contains 5 PFTA repeats.

Research Articles on FNTA

1. our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FNTA antibody

Reference Product	PubMed Publications
FNTB antibody	>3 publications with FNTA and FNTB
KRAS antibody	>1 publications with FNTA and KRAS

Pathways associated with anti-FNTA antibody

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Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Cleavage Of Cellular Proteins Pathway antibodies	Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Associated With Visual Transduction Pathway antibodies	Diseases Associated With Visual Transduction Pathway Diagram
Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway antibodies	Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
TGF-beta Receptor Signaling Pathway antibodies	TGF-beta Receptor Signaling Pathway Diagram
Terpenoid Backbone Biosynthesis Pathway antibodies	Terpenoid Backbone Biosynthesis Pathway Diagram
Terpenoid Backbone Biosynthesis Pathway antibodies	Terpenoid Backbone Biosynthesis Pathway Diagram

Diseases associated with anti-FNTA antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with FNTA and Neoplasms
Lung Neoplasms Antibodies	>1 publications with FNTA and Lung Neoplasms
Brain Diseases Antibodies	>1 publications with FNTA and Brain Diseases
Nervous System Diseases Antibodies	>1 publications with FNTA and Nervous System Diseases
Breast Neoplasms Antibodies	>1 publications with FNTA and Breast Neoplasms
Disease Models, Animal Antibodies	>1 publications with FNTA and Disease Models, Animal
Hemorrhage Antibodies	>1 publications with FNTA and Hemorrhage
Immune System Diseases Antibodies	>1 publications with FNTA and Immune System Diseases
Cognition Disorders Antibodies	>1 publications with FNTA and Cognition Disorders
Weight Loss Antibodies	>1 publications with FNTA and Weight Loss

Organs/Tissues associated with anti-FNTA antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with FNTA and Liver
Connective Tissue Antibodies	>2 publications with FNTA and Connective Tissue
Adipose Tissue Antibodies	>2 publications with FNTA and Adipose Tissue
Lymph Node Antibodies	>1 publications with FNTA and Lymph Node
Bone Antibodies	>1 publications with FNTA and Bone
Thyroid Antibodies	>1 publications with FNTA and Thyroid
Blood Antibodies	>1 publications with FNTA and Blood
Skin Antibodies	>1 publications with FNTA and Skin
Adrenal Gland Antibodies	>1 publications with FNTA and Adrenal Gland
Nerve Antibodies	>1 publications with FNTA and Nerve