Mouse Anti-TNRC6C Monoclonal Antibody – Cat# MBS646798

TNRC6C Antibody – Mouse Monoclonal

Name: TNRC6C Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646798
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646798

MBS646798 is an antibody targeting TNRC6C. Also known as TNRC6C (Trinucleotide Repeat-containing Gene 6C Protein, KIAA1582). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TNRC6C, Monoclonal Antibody

Full Product Name

TNRC6C (Trinucleotide Repeat-containing Gene 6C Protein, KIAA1582)

Product Gene Name

anti-TNRC6C antibody

Product Synonym Names

Anti -TNRC6C (Trinucleotide Repeat-containing Gene 6C Protein, KIAA1582)

Immunogen Sequence

TDGPNNTNPM NSSPNPINAM QTNGLPNWGM AVGMGAIIPP HLQGLPGANG SSVSQVSGGS AEGISNSVWG LSPGNPATGN SNSGFSQGNG DTVNSALSAK

Clonality

Monoclonal

Isotype

IgG2a,k

Clone Number

3G11

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human TNRC6C.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

175,964 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (76000194..76104916). Location: 17q25.3

OMIM

610741

3D Structure

ModBase 3D Structure for Q9HCJ0

Immunogen

Partial recombinant corresponding to aa181-280 from human TNRC6C (NP_061869) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-TNRC6C antibody

Antibodies; Abs to RNA Processing

Applications Tested/Suitable for anti-TNRC6C antibody

ELISA (EL/EIA)

Application Notes for anti-TNRC6C antibody

Suitable for use in ELISA.

Other Notes

Small volumes of anti-TNRC6C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNRC6C. It may not necessarily be applicable to this product.

NCBI GI #

217416332

NCBI GeneID

57690

NCBI Accession #

NP_001136112.1

UniProt Primary Accession #

Q9HCJ0

UniProt Secondary Accession #

Q86UE5; Q8N3D8; Q96MU9

UniProt Related Accession #

Q9HCJ0

GenBank Nucleotide #

NM_001142640.1

NCBI Official Full Name

trinucleotide repeat-containing gene 6C protein isoform 1

NCBI Official Synonym Full Names

trinucleotide repeat containing 6C

NCBI Official Symbol

TNRC6C

UniProt Protein Name

Trinucleotide repeat-containing gene 6C protein

Protein Family

Trinucleotide repeat-containing gene 6C protein

UniProt Gene Name

TNRC6C

UniProt Synonym Gene Names

KIAA1582

UniProt Entry Name

TNR6C_HUMAN

NCBI Protein Information

trinucleotide repeat-containing gene 6C protein

UniProt Comments for TNRC6C

Function: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Ref.8 Ref.11 Ref.12 Ref.13

Subunit structure: Interacts with one or more of the argonaute family proteins AGO1, AGO2, AGO3 and AGO4. Interacts with PABPC1 and EIF4G1. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex. Ref.7 Ref.8 Ref.9 Ref.11 Ref.12 Ref.13

Domain: The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression, including both translational inhibition and mRNA degradation.

Sequence similarities: Belongs to the GW182 family.Contains 1 RRM (RNA recognition motif) domain.Contains 1 UBA domain.

Sequence caution: The sequence BAB13408.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB71179.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on TNRC6C

1. These findings reveal that despite species-specific differences in the relative strength of the PABPC1-binding sites, the interaction between GW182 proteins and PABPC1 is critical for miRNA-mediated silencing in animal cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TNRC6C antibody

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Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies	Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
GAB1 Signalosome Pathway antibodies	GAB1 Signalosome Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram

Diseases associated with anti-TNRC6C antibody

Disease Name	Pubmed Publications
Growth Disorders Antibodies	>1 publications with TNRC6C and Growth Disorders
Neoplasms Antibodies	>1 publications with TNRC6C and Neoplasms

Organs/Tissues associated with anti-TNRC6C antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>1 publications with TNRC6C and Nerve
Brain Antibodies	>1 publications with TNRC6C and Brain