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CTPS1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646805

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CTPS (CTPS1), Monoclonal Antibody
Full Product Name
CTPS (CTP Synthase 1, CTP Synthetase 1, UTP-ammonia Ligase 1, CTPS1)
Product Gene Name
anti-CTPS1 antibody
Product Synonym Names
Anti -CTPS (CTP Synthase 1, CTP Synthetase 1, UTP-ammonia Ligase 1, CTPS1)
Immunogen Sequence
MKYILVTGGV ISGIGKGIIA SSVGTILKSC GLHVTSIKID PYINIDAGTF SPYEHGEVFV LDDGGEVDLD LGNYERFLDI RLTKDNNLTT GKIYQYVINK ERKGDYLGKT VQVVPHITDA IQEWVMRQAL IPVDEDGLEP QVCVIELGGT VGDIESMPFI EAFRQFQFKV KRENFCNIHV SLVPQPSSTG EQKTKPTQNS VRELRGLGLS PDLVVCRCSN PLDTSVKEKI SMFCHVEPEQ VICVHDVSSI YRVPLLLEEQ GVVDYFLRRL DLPIERQPRK MLMKWKEMAD RYDRLLETCS IALVGKYTKF SDSYASVIKA LEHSALAINH KLEIKYIDSA DLEPITSQEE PVRYHEAWQK LCSAHGVLVP GGFGVRGTEG KIQAIAWARN QKKPFLGVCL GMQLAVVEFS RNVLGWQDAN STEFDPTTSH PVVVDMPEHN PGQMGGTMRL GKRRTLFQTK NSVMRKLYGD ADYLEERHRH RFEVNPVWKK CLEEQGLKFV GQDVEGERME IVELEDHPFF VGVQYHPEFL SRPIKPSPPY FGLLLASVGR LSHYLQKGCR LSPRDTYSDR IGSSSPDSEI TELKFPSINH D
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
2G7-1D10
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CTPS.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
66,690 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (41445007..41478237). Location: 1p34.1
OMIM
123860
3D Structure
ModBase 3D Structure for P17812
Immunogen
Full length recombinant corresponding to aa1-591 from human CTPS (AAH09408) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-CTPS1 antibody

Antibodies; Abs to Enzymes; Synthase
Applications Tested/Suitable for anti-CTPS1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CTPS1 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-CTPS1 antibody

Western Blot detection against Immunogen (90.75kD).
Mouse Anti-CTPS1 Monoclonal Antibody – Cat# MBS646805

Other Notes

Small volumes of anti-CTPS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTPS1 purchase

MBS646805 is an antibody targeting CTPS1. Also known as CTPS (CTP Synthase 1, CTP Synthetase 1, UTP-ammonia Ligase 1, CTPS1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CTPS1. It may not necessarily be applicable to this product.

NCBI GI #
148491070
NCBI GeneID
1503
NCBI Accession #
NP_001896.2
UniProt Primary Accession #
P17812
UniProt Secondary Accession #
Q5VW67; Q96GK6; D3DPW1
UniProt Related Accession #
P17812
GenBank Nucleotide #
NM_001905.2
NCBI Official Full Name
CTP synthase 1
NCBI Official Synonym Full Names
CTP synthase 1
NCBI Official Symbol
CTPS1
NCBI Official Synonym Symbols
CTPS
UniProt Protein Name
CTP synthase 1
UniProt Synonym Protein Names
CTP synthetase 1; UTP--ammonia ligase 1
Protein Family
CTP synthase
UniProt Gene Name
CTPS1
UniProt Synonym Gene Names
CTPS
UniProt Entry Name
PYRG1_HUMAN
NCBI Protein Information
CTP synthase 1; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cytidine 5-prime triphosphate synthetase

NCBI Summary for CTPS1

The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types [provided by RefSeq, Jul 2008]
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UniProt Comments for CTPS1

Function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Ref.5

Catalytic activity: ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.

Enzyme regulation: Activated by GTP and inhibited by CTP.

Pathway: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.

Sequence similarities: Belongs to the CTP synthase family.Contains 1 glutamine amidotransferase type-1 domain.
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Research Articles on CTPS1

1. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CTPS1 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram
 UTP And CTP De Novo Biosynthesis Pathway antibodies  UTP And CTP De Novo Biosynthesis Pathway Diagram
 UTP And CTP Dephosphorylation I Pathway antibodies  UTP And CTP Dephosphorylation I Pathway Diagram
 UTP And CTP Dephosphorylation II Pathway antibodies  UTP And CTP Dephosphorylation II Pathway Diagram

Diseases associated with anti-CTPS1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with CTPS1 and Neoplasms
 Liver Diseases Antibodies  >1 publications with CTPS1 and Liver Diseases

Organs/Tissues associated with anti-CTPS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with CTPS1 and Muscle
 Blood Antibodies  >1 publications with CTPS1 and Blood
 Vascular Antibodies  >1 publications with CTPS1 and Vascular
 Liver Antibodies  >1 publications with CTPS1 and Liver
 Kidney Antibodies  >1 publications with CTPS1 and Kidney
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