Vasohibin-1 (VASH1) Antibody – Mouse Monoclonal

Function: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. Ref.5 Ref.7 Ref.8

Subcellular location: Secreted Ref.5 Ref.8.

Tissue specificity: Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions. Ref.5 Ref.8

Induction: By VEGF. Ref.5 Ref.6

Post-translational modification: 2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form.

Sequence similarities: Belongs to the vasohibin family.

Caution: Although probably secreted, it lacks a canonical signal sequence.

Sequence caution: The sequence AAD44361.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA82988.2 differs from that shown. Reason: Erroneous initiation.