MAPK15 Antibody – Rabbit Polyclonal

Function: In vitro, phosphorylates MBP. Ref.1 Ref.2

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1

By similarity.

Subunit structure: Interacts with CSK/c-Src, ABL1, RET and TGFB1I1. Ref.1 Ref.2 Ref.4

Tissue specificity: Widely expressed with a maximal expression in lung and kidney. Ref.1 Ref.2

Domain: The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation

By similarity.The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification: Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro. Ref.1Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase

By similarity.

Sequence similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain.