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SIPA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646885

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell… More details

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Product Overview

Online Datasheet in PDF
Product Name
SIPA1, Polyclonal Antibody
Full Product Name
SIPA1, CT (SIPA1, SPA1, Signal-induced proliferation-associated protein 1, GTPase-activating protein Spa-1, p130 SPA-1)
Product Gene Name
Product Synonym Names
Anti -SIPA1, CT (SIPA1, SPA1, Signal-induced proliferation-associated protein 1, GTPase-activating protein Spa-1, p130 SPA-1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
112,149 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (65405578..65418391). Location: 11q13
OMIM
602180
3D Structure
ModBase 3D Structure for Q96FS4
Immunogen
SIPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 941-970 amino acids from the C-terminal region of human SIPA1.
Applications Tested/Suitable for anti-SIPA1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SIPA1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-SIPA1 antibody

SIPA1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SIPA1 antibody detected the SIPA1 protein (arrow).
Rabbit Anti-SIPA1 Polyclonal Antibody – Cat# MBS646885

Other Notes

Small volumes of anti-SIPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIPA1 purchase

MBS646885 is an antibody targeting SIPA1. Also known as SIPA1, CT (SIPA1, SPA1, Signal-induced proliferation-associated protein 1, GTPase-activating protein Spa-1, p130 SPA-1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SIPA1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
signal-induced proliferation-associated protein 1
NCBI Official Synonym Full Names
signal-induced proliferation-associated 1
NCBI Official Symbol
SIPA1
NCBI Official Synonym Symbols
SPA1
UniProt Protein Name
Signal-induced proliferation-associated protein 1
UniProt Synonym Protein Names
GTPase-activating protein Spa-1; p130 SPA-1
UniProt Gene Name
SIPA1
UniProt Synonym Gene Names
SPA1; Sipa-1
UniProt Entry Name
SIPA1_HUMAN
NCBI Protein Information
signal-induced proliferation-associated protein 1; sipa-1; p130 SPA-1; GTPase-activating protein Spa-1; signal-induced proliferation-associated gene 1

UniProt Comments for SIPA1

Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. Ref.1

Subcellular location: Nucleus. Cytoplasm › perinuclear region. Endomembrane system; Peripheral membrane protein. Note: Mostly localized in the perinuclear membraneous region.

Tissue specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

Induction: Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.

Sequence similarities: Contains 1 PDZ (DHR) domain.Contains 1 Rap-GAP domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SIPA1 antibody

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