SCN2B Antibody – Rabbit Polyclonal

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]

Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier

By similarity.

Subunit structure: The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR

By similarity. Ref.7

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Brain specific.

Sequence similarities: Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family. [View classification]Contains 1 Ig-like C2-type (immunoglobulin-like) domain.