TNK1 Antibody – Rabbit Monoclonal

Tyrosine kinase non-receptor 1 (TNK1) is related to the Ack1 (TNK2) non-receptor kinase that binds cdc42 and inhibits GTPase activity of this cell cycle regulator. TNK1 is broadly expressed in embryogenic tissues and leukemia cell lines, but is restricted to select adult tissues (1). TNK1 is a putative 72kD protein comprised of an N-terminal kinase domain, a central SH3 domain and a proline-rich tail. Interaction with PLCy in vitro indicates a possible role in phospholipid signal transduction pathways (2). Though the exact mechanism is currently unclear, active TNK1 may play a role in regulating cell death by preventing TNF-a-induced NF-kB transactivation (3). Phosphorylation of TNK1 on Tyr277 was identified, CST's LC-MS/MS platform for phosphorylation site discovery (4) and also reported independently in another publication us- ing MS technology (5). Phosphorylation of TNK1 at Tyr277 was observed in select carcinoma cell lines and in tumors. A constitutively active, 58kD truncated TNK1 kinase result- ing from fusion between the TNK1 and C17orf61 genes is seen in some cells (5).

Small volumes of anti-TNK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS646896 is an antibody targeting TNK1. Also known as TNK1, phosphorylated (Tyr277) (Non-receptor Tyrosine-protein Kinase TNK1, CD38 Negative Kinase 1). Reactive in Human, Mouse, Rat. Host: Rabbit.