• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

numb Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646931

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NUMB, Polyclonal Antibody
Full Product Name
NUMB, NT (NUMB, Protein numb homolog, Protein S171)
Product Gene Name
Product Synonym Names
Anti -NUMB, NT (NUMB, Protein numb homolog, Protein S171)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
60,614 Da
Chromosome Location
Chromosome: 2L; NT_033779.4 (9437469..9464184). Location: 30B3-30B5
3D Structure
ModBase 3D Structure for P16554
Immunogen
NUMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NUMB.

Product Categories/Family for anti-numb antibody

Applications Tested/Suitable for anti-numb antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-numb antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-numb antibody

NUMB Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NUMB antibody detected the NUMB protein (arrow).
Rabbit Anti-numb Polyclonal Antibody – Cat# MBS646931

Immunohistochemistry (IHC) of anti-numb antibody

NUMB Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMB Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-numb Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646931

Other Notes

Small volumes of anti-numb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for numb purchase

MBS646931 is an antibody targeting numb. Also known as NUMB, NT (NUMB, Protein numb homolog, Protein S171). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for numb. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
numb, isoform D
NCBI Official Symbol
numb
NCBI Official Synonym Symbols
CG3779; d-numb; DmelCG3779; dNumb; l(2)03235; l(2)3235; l(2)s2201; N7-1; nb; Nb; Numb; numbs
UniProt Protein Name
Protein numb
Protein Family
UniProt Gene Name
numb
UniProt Entry Name
NUMB_DROME
NCBI Protein Information
CG3779 gene product from transcript CG3779-RB; CG3779-PA; CG3779-PB; CG3779-PD; d-Numb; numb; numb-PA; numb-PB; numb-PD

UniProt Comments for numb

Function: Required in determination of cell fate during sensory organ formation in embryos. Functions in nuclei and seems to interact with nucleic acids. Ref.1

Subunit structure: Interacts with Nak.

Subcellular location: Nucleus.

Domain: PTB domain recognizes multiple ligands by engaging different amounts of surface area dictated by tertiary contacts rather than primary sequence. This may allow interactions with a diverse set of proteins during asymmetric division and specification of cell fate.

Sequence similarities: Contains 1 PID domain.

Sequence caution: The sequence AAK93152.1 differs from that shown. Reason: Erroneous initiation.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000