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PKN3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646952

PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of… More details

$970 / 0.1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PKN3, Polyclonal Antibody
Full Product Name
PKN3 (Serine/Threonine-protein Kinase N3, Protein Kinase PKN-beta, Protein-kinase C-related Kinase 3, PKNBETA, RP11-545E17.1)
Product Gene Name
anti-PKN3 antibody
Product Synonym Names
Anti -PKN3 (Serine/Threonine-protein Kinase N3, Protein Kinase PKN-beta, Protein-kinase C-related Kinase 3, PKNBETA, RP11-545E17.1)
Immunogen Sequence
MEEGAPRQPG PSQWPPEDEK EVIRRAIQKE LKIKEGVENL RRVATDRRHL GHVQQLLRSS NRRLEQLHGE LRELHARILL PGPGPGPAEP VASGPRPWAE QLRARHLEAL RRQLHVELKV KQGAENMTHT CASGTPKERK LLAAAQQMLR DSQLKVALLR MKISSLEASG SPEPGPELLA EELQHRLHVE AAVAEGAKNV VKLLSSRRTQ DRKALAEAQA QLQESSQKLD LLRLALEQLL EQLPPAHPLR SRVTRELRAA VPGYPQPSGT PVKPTALTGT LQVRLLGCEQ LLTAVPGRSP AAALASSPSE GWLRTKAKHQ RGRGELASEV LAVLKVDNRV VGQTGWGQVA EQSWDQTFVI PLERARELEI GVHWRDWRQL CGVAFLRLED FLDNACHQLS LSLVPQGLLF AQVTFCDPVI ERRPRLQRQE RIFSKRRGQD FLRASQMNLG MAAWGRLVMN LLPPCSSPST ISPPKGCPRT PTTLREASDP ATPSNFLPKK TPLGEEMTPP PKPPRLYLPQ EPTSEETPRT KRPHMEPRTR RGPSPPASPT RKPPRLQDFR CLAVLGRGHF GKVLLVQFKG TGKYYAIKAL KKQEVLSRDE IESLYCEKRI LEAVGCTGHP FLLSLLACFQ TSSHACFVTE FVPGGDLMMQ IHEDVFPEPQ ARFYVACVVL GLQFLHEKKI IYRDLKLDNL LLDAQGFLKI ADFGLCKEGI GFGDRTSTFC GTPEFLAPEV LTQEAYTRAV DWWGLGVLLY EMLVGECPFP GDTEEEVFDC IVNMDAPYPG FLSVQGLEFI QKLLQKCPEK RLGAGEQDAE EIKVQPFFRT TNWQALLART IQPPFVPTLC GPADLRYFEG EFTGLPPALT PPAPHSLLTA RQQAAFRDFD FVSERFLEP
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human PKN3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
99,421 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (131464802..131483199). Location: 9q34.11
OMIM
610714
3D Structure
ModBase 3D Structure for Q6P5Z2
Immunogen
Full length human PKN3, aa1-889 (NP_037487.2).

Product Categories/Family for anti-PKN3 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-PKN3 antibody
Western Blot (WB)
Application Notes for anti-PKN3 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-PKN3 antibody

Western Blot analysis of PKN3 expression in transfected 293T cell line by PKN3 polyclonal antibody. Lane 1: PKN3 transfected lysate (99.4kD). Lane 2: Non-transfected lysate.
Rabbit Anti-PKN3 Polyclonal Antibody – Cat# MBS646952

Other Notes

Small volumes of anti-PKN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PKN3 purchase

MBS646952 is an antibody targeting PKN3. Also known as PKN3 (Serine/Threonine-protein Kinase N3, Protein Kinase PKN-beta, Protein-kinase C-related Kinase 3, PKNBETA, RP11-545E17.1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PKN3. It may not necessarily be applicable to this product.

NCBI GI #
116283712
NCBI GeneID
29941
NCBI Accession #
AAH32794.1
UniProt Primary Accession #
Q6P5Z2
UniProt Secondary Accession #
Q9UM03
UniProt Related Accession #
Q6P5Z2
NCBI Official Full Name
PKN3 protein
NCBI Official Synonym Full Names
protein kinase N3
NCBI Official Symbol
PKN3
NCBI Official Synonym Symbols
RP11-545E17.1
UniProt Protein Name
Serine/threonine-protein kinase N3
UniProt Synonym Protein Names
Protein kinase PKN-beta; Protein-kinase C-related kinase 3
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
PKN3
UniProt Synonym Gene Names
PKNBETA
UniProt Entry Name
PKN3_HUMAN
NCBI Protein Information
serine/threonine-protein kinase N3; protein kinase PKN-beta; protein-kinase C-related kinase 3

UniProt Comments for PKN3

Function: Contributes to invasiveness in malignant prostate cancer. Ref.4

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation

By similarity.

Subcellular location: Nucleus. Cytoplasm › perinuclear region. Note: Nuclear and perinuclear Golgi region. Ref.1

Tissue specificity: Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues. Ref.1

Domain: The C1 domain does not bind the diacylglycerol (DAG).

Post-translational modification: Autophosphorylated. Ref.1 Ref.4

Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Contains 3 REM (Hr1) repeats.
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Research Articles on PKN3

1. PKN3 can be considered a novel protein implicated in remodeling the actin-adherens junction, possibly by linking ICAM-1-signaling with actin/AJ dynamics.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PKN3 antibody

 Products by Pathway  Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Diseases associated with anti-PKN3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with PKN3 and Neoplasms
 Prostatic Diseases Antibodies  >3 publications with PKN3 and Prostatic Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with PKN3 and Urinary Bladder Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with PKN3 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with PKN3 and Breast Neoplasms
 Mammary Neoplasms, Animal Antibodies  >1 publications with PKN3 and Mammary Neoplasms, Animal
 Cell Transformation, Neoplastic Antibodies  >1 publications with PKN3 and Cell Transformation, Neoplastic
 Pancreatic Neoplasms Antibodies  >1 publications with PKN3 and Pancreatic Neoplasms
 Lung Neoplasms Antibodies  >1 publications with PKN3 and Lung Neoplasms
 Immune System Diseases Antibodies  >1 publications with PKN3 and Immune System Diseases

Organs/Tissues associated with anti-PKN3 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >5 publications with PKN3 and Prostate
 Lymph Antibodies  >2 publications with PKN3 and Lymph
 Testis Antibodies  >1 publications with PKN3 and Testis
 Brain Antibodies  >1 publications with PKN3 and Brain
 Lung Antibodies  >1 publications with PKN3 and Lung
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