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SYT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646988

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the… More details

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Product Overview

Online Datasheet in PDF
Product Name
SYT1, Polyclonal Antibody
Full Product Name
SYT1, CT (SYT1, SVP65, SYT, Synaptotagmin-1, Synaptotagmin I, p65)
Product Gene Name
anti-SYT1 antibody
Product Synonym Names
Anti -SYT1, CT (SYT1, SVP65, SYT, Synaptotagmin-1, Synaptotagmin I, p65)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
47,573 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (79257773..79845788). Location: 12cen-q21
OMIM
185605
3D Structure
ModBase 3D Structure for P21579
Immunogen
SYT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-377 amino acids from the C-terminal region of human SYT1.

Product Categories/Family for anti-SYT1 antibody

Antibodies; Abs to Syntaxin; Synaptotagmin; Synaptophysin
Applications Tested/Suitable for anti-SYT1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SYT1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-SYT1 antibody

SYT1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SYT1 antibody detected the SYT1 protein (arrow).
Rabbit Anti-SYT1 Polyclonal Antibody – Cat# MBS646988

Immunohistochemistry (IHC) of anti-SYT1 antibody

SYT1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SYT1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-SYT1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646988

Other Notes

Small volumes of anti-SYT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SYT1 purchase

MBS646988 is an antibody targeting SYT1. Also known as SYT1, CT (SYT1, SVP65, SYT, Synaptotagmin-1, Synaptotagmin I, p65). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SYT1. It may not necessarily be applicable to this product.

NCBI GI #
209447073
NCBI GeneID
6857
NCBI Accession #
NP_001129278.1
UniProt Primary Accession #
P21579
UniProt Secondary Accession #
Q6AI31
UniProt Related Accession #
P21579
GenBank Nucleotide #
NM_001135806.1
NCBI Official Full Name
synaptotagmin-1
NCBI Official Synonym Full Names
synaptotagmin I
NCBI Official Symbol
SYT1
NCBI Official Synonym Symbols
P65; SYT; SVP65
UniProt Protein Name
Synaptotagmin-1
UniProt Synonym Protein Names
Synaptotagmin I; SytI; p65
Protein Family
ARF guanine-nucleotide exchange factor
UniProt Gene Name
SYT1
UniProt Synonym Gene Names
SVP65; SYT; SytI
UniProt Entry Name
SYT1_HUMAN
NCBI Protein Information
synaptotagmin-1; sytI; synaptotagmin 1

UniProt Comments for SYT1

Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2.

Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains

By similarity.

Subunit structure: Homotetramer

Probable. Interacts with SCAMP5, STON2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25

By similarity. Ref.6

Subcellular location: Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle › secretory vesicle › chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note: Synaptic vesicles and chromaffin granules.

Domain: The first C2 domain mediates Ca2+-dependent phospholipid binding.The second C2 domain mediates interaction with SV2A and STN2

By similarity.

Sequence similarities: Belongs to the synaptotagmin family.Contains 2 C2 domains.
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Research Articles on SYT1

1. synaptotagmin-1 is involved in a rapid vesicular Ca(2) sequestration through a Ca(2)/H antiport

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SYT1 antibody

 Reference Product  PubMed Publications
 SNAP25 antibody  >23 publications with SYT1 and SNAP25
 FGF1 antibody  >14 publications with SYT1 and FGF1
 STX1A antibody  >13 publications with SYT1 and STX1A
 VAMP2 antibody  >12 publications with SYT1 and VAMP2
 RAB3A antibody  >9 publications with SYT1 and RAB3A
 S100A13 antibody  >9 publications with SYT1 and S100A13
 RIMS1 antibody  >3 publications with SYT1 and RIMS1
 SV2B antibody  >2 publications with SYT1 and SV2B
 STON2 antibody  >2 publications with SYT1 and STON2
 CPLX1 antibody  >1 publications with SYT1 and CPLX1

Pathways associated with anti-SYT1 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Neurotransmitter Release Cycle Pathway antibodies  Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
 Botulinum Neurotoxicity Pathway antibodies  Botulinum Neurotoxicity Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 Effects Of Botulinum Toxin Pathway antibodies  Effects Of Botulinum Toxin Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Norepinephrine Neurotransmitter Release Cycle Pathway antibodies  Norepinephrine Neurotransmitter Release Cycle Pathway Diagram

Diseases associated with anti-SYT1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >25 publications with SYT1 and Nervous System Diseases
 Brain Diseases Antibodies  >16 publications with SYT1 and Brain Diseases
 Neoplasms Antibodies  >12 publications with SYT1 and Neoplasms
 Disease Models, Animal Antibodies  >7 publications with SYT1 and Disease Models, Animal
 Inflammation Antibodies  >4 publications with SYT1 and Inflammation
 Seizures Antibodies  >4 publications with SYT1 and Seizures
 Movement Disorders Antibodies  >3 publications with SYT1 and Movement Disorders
 Learning Disorders Antibodies  >3 publications with SYT1 and Learning Disorders
 Poisoning Antibodies  >2 publications with SYT1 and Poisoning
 Pancreatic Neoplasms Antibodies  >2 publications with SYT1 and Pancreatic Neoplasms

Organs/Tissues associated with anti-SYT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >199 publications with SYT1 and Nerve
 Brain Antibodies  >120 publications with SYT1 and Brain
 Muscle Antibodies  >9 publications with SYT1 and Muscle
 Blood Antibodies  >7 publications with SYT1 and Blood
 Embryonic Tissue Antibodies  >7 publications with SYT1 and Embryonic Tissue
 Kidney Antibodies  >5 publications with SYT1 and Kidney
 Ganglia Antibodies  >5 publications with SYT1 and Ganglia
 Pituitary Gland Antibodies  >4 publications with SYT1 and Pituitary Gland
 Adrenal Gland Antibodies  >4 publications with SYT1 and Adrenal Gland
 Lung Antibodies  >4 publications with SYT1 and Lung
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