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ADSSL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647047

MBS647047 is an antibody targeting ADSSL1. Also known as ADSSL1, NT (ADSSL1, ADSS1, Adenylosuccinate synthetase isozyme 1, Adenylosuccinate synthetase, basic isozyme, Adenylosuccinate synthetase, muscle isozyme, IMP-aspartate ligase 1). Reactive in Human,… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ADSSL1, Polyclonal Antibody
Full Product Name
ADSSL1, NT (ADSSL1, ADSS1, Adenylosuccinate synthetase isozyme 1, Adenylosuccinate synthetase, basic isozyme, Adenylosuccinate synthetase, muscle isozyme, IMP-aspartate ligase 1)
Product Gene Name
anti-ADSSL1 antibody
Product Synonym Names
Anti -ADSSL1, NT (ADSSL1, ADSS1, Adenylosuccinate synthetase isozyme 1, Adenylosuccinate synthetase, basic isozyme, Adenylosuccinate synthetase, muscle isozyme, IMP-aspartate ligase 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
50,208 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (105190534..105213662). Location: 14q32.33
OMIM
612498
3D Structure
ModBase 3D Structure for Q8N142
Immunogen
ADSSL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-131 amino acids from the N-terminal region of human ADSSL1.

Product Categories/Family for anti-ADSSL1 antibody

Antibodies; Abs to Enzymes; Synthase
Applications Tested/Suitable for anti-ADSSL1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ADSSL1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-ADSSL1 antibody

ADSSL1 Antibody (N-term) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the ADSSL1 antibody detected ADSSL1 protein (arrow).
Rabbit Anti-ADSSL1 Polyclonal Antibody – Cat# MBS647047

Immunohistochemistry (IHC) of anti-ADSSL1 antibody

ADSSL1 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ADSSL1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-ADSSL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647047

Other Notes

Small volumes of anti-ADSSL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ADSSL1. It may not necessarily be applicable to this product.

NCBI GI #
40316944
NCBI GeneID
122622
NCBI Accession #
NP_954634.1
UniProt Primary Accession #
Q8N142
UniProt Secondary Accession #
Q86TT6; Q8N714
UniProt Related Accession #
Q8N142
GenBank Nucleotide #
NM_199165.1
NCBI Official Full Name
adenylosuccinate synthetase isozyme 1 isoform 1
NCBI Official Synonym Full Names
adenylosuccinate synthase like 1
NCBI Official Symbol
ADSSL1
UniProt Protein Name
Adenylosuccinate synthetase isozyme 1
UniProt Synonym Protein Names
Adenylosuccinate synthetase, basic isozyme; Adenylosuccinate synthetase, muscle isozyme; M-type adenylosuccinate synthetase; IMP--aspartate ligase 1
Protein Family
Adenylosuccinate synthetase
UniProt Gene Name
ADSSL1
UniProt Synonym Gene Names
ADSS1; AMPSase 1; AdSS 1
UniProt Entry Name
PURA1_HUMAN
NCBI Protein Information
adenylosuccinate synthetase isozyme 1; adSS 1; AMPSase 1; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase; adenylosuccinate synthetase, basic isozyme; adenylosuccinate synthetase, muscle isozyme

NCBI Summary for ADSSL1

ADSSL1 is a muscle isozyme of adenylosuccinate synthase (EC 6.3.4.4), which catalyzes the initial reaction in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP) (Sun et al., 2005 [PubMed 15786719]).[supplied by OMIM, Dec 2008]

UniProt Comments for ADSSL1

Function: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP

By similarity. HAMAP-Rule MF_03126

Catalytic activity: GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. HAMAP-Rule MF_03126

Cofactor: Binds 1 magnesium ion per subunit

By similarity. HAMAP-Rule MF_03126

Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. HAMAP-Rule MF_03126

Subunit structure: Homodimer

By similarity. HAMAP-Rule MF_03126

Subcellular location: Cytoplasm Ref.1.

Tissue specificity: Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors. Ref.1

Sequence similarities: Belongs to the adenylosuccinate synthetase family.

Sequence caution: The sequence AAH32039.1 differs from that shown. Reason: Frameshift at position 1. The sequence CAD62614.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on ADSSL1

1. A novel muscle isozyme of adenylosuccinate synthetase, human AdSSL1, is identified from human bone marrow stromal cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ADSSL1 antibody

 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Ribonucleoside Monophosphate Biosynthesis Pathway antibodies  Purine Ribonucleoside Monophosphate Biosynthesis Pathway Diagram

Organs/Tissues associated with anti-ADSSL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with ADSSL1 and Bone
 Heart Antibodies  >1 publications with ADSSL1 and Heart
 Muscle Antibodies  >1 publications with ADSSL1 and Muscle
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