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CDKL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647078

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Alternative splice variants encoding different protein isoforms have been described, but their full-length nature has… More details

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Product Overview

Online Datasheet in PDF
Product Name
CDKL1, Polyclonal Antibody
Full Product Name
CDKL1, CT (CDKL1, Cyclin-dependent kinase-like 1, Protein kinase p42 KKIALRE, Serine/threonine-protein kinase KKIALRE)
Product Gene Name
anti-CDKL1 antibody
Product Synonym Names
Anti -CDKL1, CT (CDKL1, Cyclin-dependent kinase-like 1, Protein kinase p42 KKIALRE, Serine/threonine-protein kinase KKIALRE)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
41,671 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (50796122..50883179, complement). Location: 14q21.3
OMIM
603441
3D Structure
ModBase 3D Structure for Q00532
Immunogen
CDKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293~323 amino acids from the C-terminal region of human CDKL1.

Product Categories/Family for anti-CDKL1 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-CDKL1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CDKL1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Immunohistochemistry (IHC) of anti-CDKL1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-CDKL1 Polyclonal Antibody – Cat# MBS647078

Western Blot (WB) of anti-CDKL1 antibody

The anti-CDKL1 Pab is used in Western blot to detect CDKL1 in mouse kidney tissue lysate.
Rabbit Anti-CDKL1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS647078

Western Blot (WB) of anti-CDKL1 antibody

Western blot analysis of CDKL1 (arrow) using rabbit polyclonal CDKL1 Antibody (H300) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CDKL1 gene.
Rabbit Anti-CDKL1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS647078

Western Blot (WB) of anti-CDKL1 antibody

CDKL1 Antibody (H300) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CDKL1 antibody detected the CDKL1 protein (arrow).
Rabbit Anti-CDKL1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS647078

Other Notes

Small volumes of anti-CDKL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDKL1 purchase

MBS647078 is an antibody targeting CDKL1. Also known as CDKL1, CT (CDKL1, Cyclin-dependent kinase-like 1, Protein kinase p42 KKIALRE, Serine/threonine-protein kinase KKIALRE). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDKL1. It may not necessarily be applicable to this product.

NCBI GI #
37596297
NCBI GeneID
8814
NCBI Accession #
NP_004187.2
UniProt Primary Accession #
Q00532
UniProt Secondary Accession #
Q2M3A4; Q6QUA0; Q8WXQ5
UniProt Related Accession #
Q00532
GenBank Nucleotide #
NM_004196.4
NCBI Official Full Name
cyclin-dependent kinase-like 1 isoform 1
NCBI Official Synonym Full Names
cyclin-dependent kinase-like 1 (CDC2-related kinase)
NCBI Official Symbol
CDKL1
NCBI Official Synonym Symbols
P42; KKIALRE
UniProt Protein Name
Cyclin-dependent kinase-like 1
UniProt Synonym Protein Names
Protein kinase p42 KKIALRE; Serine/threonine-protein kinase KKIALRE
Protein Family
Cyclin-dependent kinase
UniProt Gene Name
CDKL1
UniProt Entry Name
CDKL1_HUMAN
NCBI Protein Information
cyclin-dependent kinase-like 1; CDC2-related kinase 1; protein kinase p42 KKIALRE; serine/threonine protein kinase KKIALRE; serine/threonine-protein kinase KKIALRE

NCBI Summary for CDKL1

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

UniProt Comments for CDKL1

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Subcellular location: Cytoplasm. Nucleus Ref.6.

Tissue specificity: Highly expressed in kidney, and to a lower extent in ovary. Ref.6

Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Contains 1 protein kinase domain.

Sequence caution: The sequence AAI04978.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAS00095.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAA47002.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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Research Articles on CDKL1

1. CDKL1 was overexpressed in breast cancer patients and had a positive detection efficiency of 77% (144/186).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CDKL1 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with CDKL1 and Brain Diseases
 Neoplasms Antibodies  >2 publications with CDKL1 and Neoplasms
 Eye Abnormalities Antibodies  >1 publications with CDKL1 and Eye Abnormalities
 Nervous System Diseases Antibodies  >1 publications with CDKL1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >1 publications with CDKL1 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with CDKL1 and Kidney Diseases

Organs/Tissues associated with anti-CDKL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with CDKL1 and Brain
 Kidney Antibodies  >1 publications with CDKL1 and Kidney
 Eye Antibodies  >1 publications with CDKL1 and Eye
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