Rabbit Anti-TRIM2 Polyclonal Antibody – Cat# MBS647087

TRIM2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the TRIM2 antibody detected the TRIM2 protein (arrow).

TRIM2 Antibody – Rabbit Polyclonal

Name: TRIM2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647087
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647087

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. Its… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRIM2, Polyclonal Antibody

Full Product Name

TRIM2, CT (TRIM2, KIAA0517, RNF86, Tripartite motif-containing protein 2, E3 ubiquitin-protein ligase TRIM2, RING finger protein 86)

Product Gene Name

anti-TRIM2 antibody

Product Synonym Names

Anti -TRIM2, CT (TRIM2, KIAA0517, RNF86, Tripartite motif-containing protein 2, E3 ubiquitin-protein ligase TRIM2, RING finger protein 86)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

81,530 Da

Chromosome Location

Chromosome: 4; NC_000004.11 (154073650..154260474). Location: 4q31.3

OMIM

614141

3D Structure

ModBase 3D Structure for Q9C040

Immunogen

TRIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-621 amino acids from the C-terminal region of human TRIM2.

Product Categories/Family for anti-TRIM2 antibody

Antibodies; Abs to Transcription Factors; TRIM (Tripartite Motif)

Applications Tested/Suitable for anti-TRIM2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-TRIM2 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-TRIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIM2 purchase

MBS647087 is an antibody targeting TRIM2. Also known as TRIM2, CT (TRIM2, KIAA0517, RNF86, Tripartite motif-containing protein 2, E3 ubiquitin-protein ligase TRIM2, RING finger protein 86). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM2. It may not necessarily be applicable to this product.

NCBI GI #

194248081

NCBI GeneID

23321

NCBI Accession #

NP_001123539.1

UniProt Primary Accession #

Q9C040

UniProt Secondary Accession #

O60272; Q9BSI9; Q9UFZ1; D3DP09

UniProt Related Accession #

Q9C040

GenBank Nucleotide #

NM_001130067.1

NCBI Official Full Name

tripartite motif-containing protein 2 isoform 2

NCBI Official Synonym Full Names

tripartite motif containing 2

NCBI Official Symbol

TRIM2

NCBI Official Synonym Symbols

RNF86

UniProt Protein Name

Tripartite motif-containing protein 2

UniProt Synonym Protein Names

E3 ubiquitin-protein ligase TRIM2; RING finger protein 86

Protein Family

Tripartite motif-containing protein

UniProt Gene Name

TRIM2

UniProt Synonym Gene Names

KIAA0517; RNF86

UniProt Entry Name

TRIM2_HUMAN

NCBI Protein Information

tripartite motif-containing protein 2; RING finger protein 86; tripartite motif protein 2; tripartite motif-containing 2; tripartite motif protein TRIM2; E3 ubiquitin-protein ligase TRIM2

NCBI Summary for TRIM2

UniProt Comments for TRIM2

Function: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11

By similarity. Plays a neuroprotective function

By similarity. May play a role in neuronal rapid ischemic tolerance

By similarity.

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Interacts with myosin V; myosin V may not be a substrate for ubiquitination

By similarity. Interacts with NEFL

By similarity. Interacts with phosphorylated BCL2L11. Ref.7

Subcellular location: Cytoplasm

By similarity.

Domain: The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades

By similarity.

Post-translational modification: RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination

By similarity.

Sequence similarities: Belongs to the TRIM/RBCC family.Contains 1 B box-type zinc finger.Contains 1 filamin repeat.Contains 6 NHL repeats.Contains 1 RING-type zinc finger.

Sequence caution: The sequence AAG53472.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAA25443.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Research Articles on TRIM2

1. TRIM2 is repressed by miR-9 and -181c, either alone or in combination.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TRIM2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>4 publications with TRIM2 and Nervous System Diseases
Carcinoma Antibodies	>4 publications with TRIM2 and Carcinoma
Adenocarcinoma Antibodies	>2 publications with TRIM2 and Adenocarcinoma
Skin Diseases Antibodies	>1 publications with TRIM2 and Skin Diseases
Uterine Cervical Neoplasms Antibodies	>1 publications with TRIM2 and Uterine Cervical Neoplasms
Weight Loss Antibodies	>1 publications with TRIM2 and Weight Loss
Ataxia Antibodies	>1 publications with TRIM2 and Ataxia
Neoplasm Metastasis Antibodies	>1 publications with TRIM2 and Neoplasm Metastasis
Lung Neoplasms Antibodies	>1 publications with TRIM2 and Lung Neoplasms
Breast Neoplasms Antibodies	>1 publications with TRIM2 and Breast Neoplasms

Organs/Tissues associated with anti-TRIM2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with TRIM2 and Brain
Nerve Antibodies	>3 publications with TRIM2 and Nerve
Bone Antibodies	>1 publications with TRIM2 and Bone
Salivary Gland Antibodies	>1 publications with TRIM2 and Salivary Gland
Thyroid Antibodies	>1 publications with TRIM2 and Thyroid
Vascular Antibodies	>1 publications with TRIM2 and Vascular
Mouth Antibodies	>1 publications with TRIM2 and Mouth
Muscle Antibodies	>1 publications with TRIM2 and Muscle
Lung Antibodies	>1 publications with TRIM2 and Lung