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PHF17 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647151

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PHF17, Polyclonal Antibody
Full Product Name
PHF17, NT (PHF17, JADE1, KIAA1807, Protein Jade-1, PHD finger protein 17)
Product Gene Name
anti-PHF17 antibody
Product Synonym Names
Anti -PHF17, NT (PHF17, JADE1, KIAA1807, Protein Jade-1, PHD finger protein 17)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
95,533 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (129730779..129796379). Location: 4q26-q27
OMIM
610514
3D Structure
ModBase 3D Structure for Q6IE81
Immunogen
PHF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-51 amino acids from the N-terminal region of human PHF17.

Product Categories/Family for anti-PHF17 antibody

Antibodies; Abs to KIAA; orf
Applications Tested/Suitable for anti-PHF17 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PHF17 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-PHF17 antibody

PHF17 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PHF17 antibody detected the PHF17 protein (arrow).
Rabbit Anti-PHF17 Polyclonal Antibody – Cat# MBS647151

Immunohistochemistry (IHC) of anti-PHF17 antibody

PHF17 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PHF17 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PHF17 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647151

Other Notes

Small volumes of anti-PHF17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHF17 purchase

MBS647151 is an antibody targeting PHF17. Also known as PHF17, NT (PHF17, JADE1, KIAA1807, Protein Jade-1, PHD finger protein 17). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PHF17. It may not necessarily be applicable to this product.

NCBI GI #
21595374
NCBI GeneID
79960
NCBI Accession #
AAH32376.1
UniProt Primary Accession #
Q6IE81
UniProt Secondary Accession #
Q4W5D5; Q6ZSL7; Q8NC41; Q96JL8; Q96SQ1; Q9H692; D3DNY0; D3DNY1
UniProt Related Accession #
Q6IE81
NCBI Official Full Name
PHF17 protein
NCBI Official Synonym Full Names
PHD finger protein 17
NCBI Official Symbol
PHF17
NCBI Official Synonym Symbols
JADE1
UniProt Protein Name
Protein Jade-1
UniProt Synonym Protein Names
PHD finger protein 17
UniProt Gene Name
PHF17
UniProt Synonym Gene Names
JADE1; KIAA1807
UniProt Entry Name
JADE1_HUMAN
NCBI Protein Information
protein Jade-1; PHD protein Jade-1; gene for apoptosis and differentiation in epithelia

UniProt Comments for PHF17

Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Ref.8 Ref.9 Ref.10

Subunit structure: Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Isoform 3 interacts with VHL and KAT5. Ref.1 Ref.8 Ref.10

Subcellular location: Cytoplasm. Nucleus Ref.1 Ref.8.

Tissue specificity: Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. Ref.1 Ref.9

Domain: The 2 PHD-type zinc fingers are required for transcriptional activity.

Sequence similarities: Belongs to the JADE family.Contains 2 PHD-type zinc fingers.

Sequence caution: The sequence BAB15371.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11335.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on PHF17

1. A key target of polycystin-1, the cyclin-dependent kinase inhibitor p21, is up-regulated by Jade-1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PHF17 antibody

 Reference Product  PubMed Publications
 VHL antibody  >8 publications with PHF17 and VHL
 KAT5 antibody  >1 publications with PHF17 and KAT5

Diseases associated with anti-PHF17 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >7 publications with PHF17 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >2 publications with PHF17 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >2 publications with PHF17 and Adenocarcinoma
 Brain Diseases Antibodies  >1 publications with PHF17 and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with PHF17 and Nervous System Diseases

Organs/Tissues associated with anti-PHF17 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >7 publications with PHF17 and Kidney
 Placenta Antibodies  >1 publications with PHF17 and Placenta
 Embryonic Tissue Antibodies  >1 publications with PHF17 and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >1 publications with PHF17 and Uncharacterized Tissue
 Brain Antibodies  >1 publications with PHF17 and Brain
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