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VPS18 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647182

MBS647182 is an antibody targeting VPS18. Also known as VPS18 (Vacuolar Protein Sorting-associated Protein 18 Homolog, hVPS18, KIAA1475, PEP3). Reactive in Human, Mouse. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
VPS18, Monoclonal Antibody
Full Product Name
VPS18 (Vacuolar Protein Sorting-associated Protein 18 Homolog, hVPS18, KIAA1475, PEP3)
Product Gene Name
anti-VPS18 antibody
Product Synonym Names
Anti -VPS18 (Vacuolar Protein Sorting-associated Protein 18 Homolog, hVPS18, KIAA1475, PEP3)
Immunogen Sequence
SILDEYENSL SRSAVLQPGC PSVGIPHSGY VNAQLEKEVP IFTKQRIDFT PSERITSLVV SSNQLCMSLG KDTLLRIDLG KANEPNHVEL GRKDDAKV
Clonality
Monoclonal
Isotype
IgG3,k
Clone Number
2G10
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human VPS18. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
110,186 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (41186628..41196173). Location: 15q14-q15
OMIM
608551
3D Structure
ModBase 3D Structure for Q9P253
Immunogen
Partial recombinant corresponding to aa3-101 from human VPS18 (NP_065908) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-VPS18 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-VPS18 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-VPS18 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-VPS18 antibody

Western Blot detection against Immunogen (36.89kD).
Mouse Anti-VPS18 Monoclonal Antibody – Cat# MBS647182

Western Blot (WB) of anti-VPS18 antibody

VPS18 monoclonal antibody. Western Blot analysis of VPS18 expression in Raw 264.7.
Mouse Anti-VPS18 Monoclonal Antibody, Western Blot (WB) – Cat# MBS647182

Testing Data of anti-VPS18 antibody

Detection limit for recombinant GST tagged VPS18 is ~3ng/ml as a capture antibody.
Mouse Anti-VPS18 Monoclonal Antibody, Testing Data – Cat# MBS647182

Other Notes

Small volumes of anti-VPS18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS18. It may not necessarily be applicable to this product.

NCBI GI #
17978485
NCBI GeneID
57617
NCBI Accession #
NP_065908.1
UniProt Primary Accession #
Q9P253
UniProt Secondary Accession #
Q8TCG0; Q96DI3; Q9H268
UniProt Related Accession #
Q9P253
GenBank Nucleotide #
NM_020857.2
NCBI Official Full Name
vacuolar protein sorting-associated protein 18 homolog
NCBI Official Synonym Full Names
vacuolar protein sorting 18 homolog (S. cerevisiae)
NCBI Official Symbol
VPS18
NCBI Official Synonym Symbols
PEP3
UniProt Protein Name
Vacuolar protein sorting-associated protein 18 homolog
Protein Family
Vacuolar protein sorting-associated protein
UniProt Gene Name
VPS18
UniProt Synonym Gene Names
KIAA1475; hVPS18
UniProt Entry Name
VPS18_HUMAN
NCBI Protein Information
vacuolar protein sorting-associated protein 18 homolog; hVPS18; vacuolar protein sorting protein 18

NCBI Summary for VPS18

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]
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UniProt Comments for VPS18

Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Ref.5

Subunit structure: Interacts with HOOK1

By similarity. Part of a large heterooligomeric complex together with VPS11, VPS16 and VPS33A. Interacts with STX7. Ref.5

Subcellular location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Ref.5 Ref.6

Tissue specificity: Ubiquitous. Expression was highest in heart and low in lung. Ref.5

Sequence similarities: Belongs to the VPS18 family.Contains 1 CHCR (clathrin heavy-chain) repeat.Contains 1 RING-type zinc finger.

Sequence caution: The sequence AAH01513.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.The sequence BAA95999.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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Research Articles on VPS18

1. Depletion of hVps18 or hMon2 reduced the efficient production of infectious HIV-1 virions in human cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VPS18 antibody

 Reference Product  PubMed Publications
 VPS11 antibody  >12 publications with VPS18 and VPS11
 VPS16 antibody  >10 publications with VPS18 and VPS16
 VPS41 antibody  >5 publications with VPS18 and VPS41
 VPS39 antibody  >4 publications with VPS18 and VPS39
 VPS33A antibody  >1 publications with VPS18 and VPS33A
 GGA3 antibody  >1 publications with VPS18 and GGA3

Diseases associated with anti-VPS18 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with VPS18 and Liver Diseases
 Hypertrophy Antibodies  >2 publications with VPS18 and Hypertrophy
 Brain Diseases Antibodies  >1 publications with VPS18 and Brain Diseases
 Fatty Liver Antibodies  >1 publications with VPS18 and Fatty Liver
 Disease Models, Animal Antibodies  >1 publications with VPS18 and Disease Models, Animal
 Neoplasms Antibodies  >1 publications with VPS18 and Neoplasms

Organs/Tissues associated with anti-VPS18 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >3 publications with VPS18 and Nerve
 Eye Antibodies  >3 publications with VPS18 and Eye
 Brain Antibodies  >3 publications with VPS18 and Brain
 Skin Antibodies  >3 publications with VPS18 and Skin
 Embryonic Tissue Antibodies  >2 publications with VPS18 and Embryonic Tissue
 Kidney Antibodies  >1 publications with VPS18 and Kidney
 Liver Antibodies  >1 publications with VPS18 and Liver
 Uncharacterized Tissue Antibodies  >1 publications with VPS18 and Uncharacterized Tissue
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