VWC2 Antibody – Sheep Polyclonal

Function: BMP antagonist which may play a role in neural development. Promotes cell adhesion. Ref.1 Ref.7

Subunit structure: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Ref.8

Subcellular location: Secreted › extracellular space › extracellular matrix › basement membrane. Cell junction › synapse

Probable Ref.1 Ref.7 Ref.8.

Tissue specificity: Predominantly expressed in the brain (at protein level). It is expressed in the neurons but not the glial cells. Ref.1 Ref.7 Ref.8

Developmental stage: At 12.5 dpc, predominantly expressed in the developing diencephalon. At 16.5 dpc and 18.5 dpc, expressed in the brain, spinal cord, developing neural tubes and tongue but not in the cerebral cortex. At 16.5 dpc, present in developing oral and tooth germ epithelia (at protein level). Ref.1 Ref.7

Sequence similarities: Contains 2 VWFC domains.

Sequence caution: The sequence CAI25053.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.