Mouse Anti-SPG11 Polyclonal Antibody – Cat# MBS647211

Western Blot analysis of SPG11 expression in transfected 293T cell line by SPG11 polyclonal antibody. Lane 1: FLJ21439 transfected lysate (46.75kD). Lane 2: Non-transfected lysate.

SPG11 Antibody – Mouse Polyclonal

Name: SPG11 Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647211
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647211

MBS647211 is an antibody targeting SPG11. Also known as SPG11 (Spatacsin, Colorectal Carcinoma-associated Protein, Spastic Paraplegia 11 Protein, KIAA1840, FLJ21439, DKFZp762B1512, FLJ21439). Reactive in Human. Host: Mouse. Interacts with AP5Z1, AP5B1, AP5S1… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SPG11, Polyclonal Antibody

Full Product Name

SPG11 (Spatacsin, Colorectal Carcinoma-associated Protein, Spastic Paraplegia 11 Protein, KIAA1840, FLJ21439, DKFZp762B1512, FLJ21439)

Product Gene Name

anti-SPG11 antibody

Product Synonym Names

Anti -SPG11 (Spatacsin, Colorectal Carcinoma-associated Protein, Spastic Paraplegia 11 Protein, KIAA1840, FLJ21439, DKFZp762B1512, FLJ21439)

Immunogen Sequence

MLRKILASQQ PDRCKRAQAF ISTQGLKPDT VAELVAEEVT RELLTSSQGT GHKQMFNPTE ESQTFLQLTT LCQDRTLVGM KLLDKISSVP HGELSCTTEL LILAHHCFTL TCHMEGIIRV LQAAHMLTDN HLAPSEEYGL VVRLLTGIGR YNEMTYIFDL LHKKHYFEVL MRKKLDPSGT LKTALLDYIK RCRPGDSEKH NMIALCFSMC REIGENHEAA ARIQLKLIES QPWEDSLKDG HQLKQLLLKA LTLMLDAAES YAKDSCVRQA QHCQRLTKLI TLQIHFLNTG QNTMLINLGR HKLMDCILAL PRFYQASIVA EAYDFVPDWA EILYQQVILK GDFNYLEEFK QQRLLKSSIF EEISKKYKQH QPTDMVMENL KKLLTYCEDV YLYYKLAYEH KFYEIVNVLL KDPQTGCCLK DMLAG

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human FLJ21439.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

278,868 Da

Chromosome Location

Chromosome: 15; NC_000015.9 (44854894..44955876, complement). Location: 15q14

OMIM

604360

3D Structure

ModBase 3D Structure for Q96JI7

Immunogen

Full length human FLJ21439, aa1-425 (AAH24161.1).

Product Categories/Family for anti-SPG11 antibody

Antibodies; Abs to Cancer Markers

Applications Tested/Suitable for anti-SPG11 antibody

Western Blot (WB)

Application Notes for anti-SPG11 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-SPG11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPG11. It may not necessarily be applicable to this product.

NCBI GI #

237681069

NCBI GeneID

80208

NCBI Accession #

NP_001153699.1

UniProt Primary Accession #

Q96JI7

UniProt Secondary Accession #

Q4VC11; Q58G86; Q69YG6; Q6NW01; Q8N270; Q8TBU9; Q9H734; A8KAX9; B9EK60; F5H3N6

UniProt Related Accession #

Q96JI7

GenBank Nucleotide #

NM_001160227.1

NCBI Official Full Name

spatacsin isoform 2

NCBI Official Synonym Full Names

spastic paraplegia 11 (autosomal recessive)

NCBI Official Symbol

SPG11

NCBI Official Synonym Symbols

KIAA1840

UniProt Protein Name

Spatacsin

UniProt Synonym Protein Names

Colorectal carcinoma-associated protein; Spastic paraplegia 11 protein

Protein Family

Spatacsin

UniProt Gene Name

SPG11

UniProt Synonym Gene Names

KIAA1840

UniProt Entry Name

SPTCS_HUMAN

NCBI Protein Information

spatacsin; spastic paraplegia 11 protein; colorectal carcinoma-associated protein

NCBI Summary for SPG11

The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

UniProt Comments for SPG11

Subunit structure: Interacts with AP5Z1, AP5B1, AP5S1 and ZFYVE26. Ref.10

Subcellular location: Membrane; Multi-pass membrane protein

Potential. Cytoplasm › cytosol. Nucleus. Note: Mainly cytoplasmic. Ref.8

Tissue specificity: Expressed in all structures of brain, with a high expression in cerebellum. Ref.8

Involvement in disease: Spastic paraplegia 11, autosomal recessive (SPG11) [MIM:604360]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Ref.11

Sequence caution: The sequence AAH24161.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAX54692.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAB15065.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAC03600.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Research Articles on SPG11

1. This study widens the spectrum of mutations in SPG11

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SPG11 antibody

Disease Name	Pubmed Publications
Neurodegenerative Diseases Antibodies	>54 publications with SPG11 and Neurodegenerative Diseases
Spastic paraplegia 11, autosomal recessive Antibodies	>4 publications with SPG11 and Spastic paraplegia 11, autosomal recessive