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COG2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647225

COG2 encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for… More details

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Product Overview

Online Datasheet in PDF
Product Name
COG2, Polyclonal Antibody
Full Product Name
COG2, NT (COG2, LDLC, Conserved oligomeric Golgi complex subunit 2, Component of oligomeric Golgi complex 2, Low density lipoprotein receptor defect C-complementing protein)
Product Gene Name
Product Synonym Names
Anti -COG2, NT (COG2, LDLC, Conserved oligomeric Golgi complex subunit 2, Component of oligomeric Golgi complex 2, Low density lipoprotein receptor defect C-complementing protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
83,208 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (230778202..230829731). Location: 1q42.2
OMIM
606974
3D Structure
ModBase 3D Structure for Q14746
Immunogen
COG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103~132 amino acids from the N-terminal region of human COG2.

Product Categories/Family for anti-COG2 antibody

Applications Tested/Suitable for anti-COG2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-COG2 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-COG2 antibody

Western blot analysis of COG2 Antibody (N-term) in Hela cell line lysates (35ug/lane). COG2 (arrow) was detected using the purified Pab.
Rabbit Anti-COG2 Polyclonal Antibody – Cat# MBS647225

Immunohistochemistry (IHC) of anti-COG2 antibody

COG2 Antibody (N-term) (RB17913) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the COG2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-COG2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647225

Flow Cytometry (FC/FACS) of anti-COG2 antibody

COG2 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-COG2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS647225

Other Notes

Small volumes of anti-COG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COG2 purchase

MBS647225 is an antibody targeting COG2. Also known as COG2, NT (COG2, LDLC, Conserved oligomeric Golgi complex subunit 2, Component of oligomeric Golgi complex 2, Low density lipoprotein receptor defect C-complementing protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COG2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
conserved oligomeric Golgi complex subunit 2 isoform 2
NCBI Official Synonym Full Names
component of oligomeric golgi complex 2
NCBI Official Symbol
COG2
NCBI Official Synonym Symbols
LDLC
UniProt Protein Name
Conserved oligomeric Golgi complex subunit 2
UniProt Synonym Protein Names
Component of oligomeric Golgi complex 2; Low density lipoprotein receptor defect C-complementing protein
UniProt Gene Name
COG2
UniProt Synonym Gene Names
LDLC; COG complex subunit 2
UniProt Entry Name
COG2_HUMAN
NCBI Protein Information
conserved oligomeric Golgi complex subunit 2; COG complex subunit 2; conserved oligomeric Golgi complex protein 2; brefeldin A-sensitive, peripheral Golgi protein; low density lipoprotein receptor defect C complementing; low density lipoprotein receptor defect C-complementing protein

NCBI Summary for COG2

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
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UniProt Comments for COG2

Function: Required for normal Golgi morphology and function.

Subunit structure: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

Subcellular location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side

Probable.

Sequence similarities: Belongs to the COG2 family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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