Rabbit Anti-DERL2 Polyclonal Antibody – Cat# MBS6472270

DERL2 Antibody – Rabbit Polyclonal

Name: DERL2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6472270
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6472270

MBS6472270 is an antibody targeting DERL2. Also known as DERL2, CT (Derlin-2, Der1-like Protein 2, Degradation In Endoplasmic Reticulum Protein 2, DERtrin-2, F-LAN-1, F-LANa, SBBI53, CGI-101, FLANA, DER2) (MaxLight 650). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DERL2, Polyclonal Antibody

Full Product Name

DERL2, CT (Derlin-2, Der1-like Protein 2, Degradation In Endoplasmic Reticulum Protein 2, DERtrin-2, F-LAN-1, F-LANa, SBBI53, CGI-101, FLANA, DER2) (MaxLight 650)

Product Gene Name

anti-DERL2 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

Purity/Purification

Purified by Immunoaffinity chromatography.

Specificity

Recognizes human DERL2.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

27,567 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (5377613..5389497, complement). Location: 17p13.2

OMIM

610304

3D Structure

ModBase 3D Structure for Q9GZP9

Immunogen

Synthetic peptide selected from the C-terminal region of human DERL2 (KLH).

Conjugate

MaxLight650

Note

Preservative Free

Product Categories/Family for anti-DERL2 antibody

Antibodies; Membrane Proteins

Applications Tested/Suitable for anti-DERL2 antibody

Western Blot (WB), FLISA

Application Notes for anti-DERL2 antibody

WB: 1:100-1:500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-DERL2 antibody

1. Lilley, B.N.et.al., Nature 429(6994), 834-840 (2004).

Other Notes

Small volumes of anti-DERL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DERL2. It may not necessarily be applicable to this product.

NCBI GI #

31455614

NCBI GeneID

51009

NCBI Accession #

NP_057125.2

UniProt Primary Accession #

Q9GZP9

UniProt Secondary Accession #

Q9Y3A7

UniProt Related Accession #

Q9GZP9

GenBank Nucleotide #

NM_016041.3

NCBI Official Full Name

derlin-2

NCBI Official Synonym Full Names

Der1-like domain family, member 2

NCBI Official Symbol

DERL2

NCBI Official Synonym Symbols

FLANa; F-LANa; CGI-101; F-LAN-1

UniProt Protein Name

Derlin-2

UniProt Synonym Protein Names

Degradation in endoplasmic reticulum protein 2; DERtrin-2; Der1-like protein 2; F-LAN-1; F-LANa

Protein Family

Derlin

UniProt Gene Name

DERL2

UniProt Synonym Gene Names

DER2; FLANA

UniProt Entry Name

DERL2_HUMAN

NCBI Protein Information

derlin-2; DERtrin-2; carcinoma related; OTTHUMP00000128204; der1-like protein 2; degradation in endoplasmic reticulum protein 2

NCBI Summary for DERL2

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM]

UniProt Comments for DERL2

DERL2: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. Belongs to the derlin family.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; early endosome; late endosome; integral to endoplasmic reticulum membrane

Molecular Function: protein binding

Biological Process: retrograde protein transport, ER to cytosol; ER-associated protein catabolic process; suckling behavior; unfolded protein response; positive regulation of cell proliferation; positive regulation of cell growth

Research Articles on DERL2

1. Required for Polyoma virus infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DERL2 antibody

Products by Pathway	Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-DERL2 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>2 publications with DERL2 and Carcinoma
Carcinoma, Hepatocellular Antibodies	>2 publications with DERL2 and Carcinoma, Hepatocellular
Neoplasms Antibodies	>2 publications with DERL2 and Neoplasms
Liver Diseases Antibodies	>1 publications with DERL2 and Liver Diseases
Adenocarcinoma Antibodies	>1 publications with DERL2 and Adenocarcinoma
Fetal Death Antibodies	>1 publications with DERL2 and Fetal Death
Neoplasms, Experimental Antibodies	>1 publications with DERL2 and Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>1 publications with DERL2 and Cell Transformation, Neoplastic
Liver Neoplasms Antibodies	>1 publications with DERL2 and Liver Neoplasms

Organs/Tissues associated with anti-DERL2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with DERL2 and Liver
Blood Antibodies	>1 publications with DERL2 and Blood
Kidney Antibodies	>1 publications with DERL2 and Kidney
Embryonic Tissue Antibodies	>1 publications with DERL2 and Embryonic Tissue