NAA15 Antibody – Rabbit Polyclonal

Function: The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. Ref.2 Ref.9 Ref.10

Subunit structure: Interacts with NAA10, XRCC6, NAA50, XRCC5 and HYPK. Associates with HYPK when in a complex with NAA10. Ref.2 Ref.10 Ref.12 Ref.18

Subcellular location: Cytoplasm. Nucleus. Note: Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes. Ref.3 Ref.10

Tissue specificity: Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy. Ref.1 Ref.3 Ref.9

Post-translational modification: Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.

Sequence similarities: Contains 8 TPR repeats.

Sequence caution: The sequence AAH39818.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.