HIST1H1A Antibody – Rabbit Polyclonal

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]

Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation

By similarity.

Subunit structure: Interacts with DFFB. Ref.8

Subcellular location: Nucleus. Chromosome. Note: Mainly localizes in euchromatin. Ref.7

Domain: The C-terminal domain is required for high-affinity binding to chromatin. Ref.6

Post-translational modification: H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter

By similarity.

Sequence similarities: Belongs to the histone H1/H5 family.Contains 1 H15 (linker histone H1/H5 globular) domain.