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RIMS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647404

RIMS2 is a Rab effector involved in exocytosis. It may act as a scaffold protein. The mature cytomatrix at the active zone (CAZ) of the synapse is defined by a set of multidomain proteins that harbor several protein-protein or protein-lipid interaction… More details

$915 / 0.05 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RIMS2, Polyclonal Antibody
Full Product Name
RIMS2, ID (Regulating Synaptic Membrane Exocytosis Protein 2, Rab3-interacting Molecule 2, RIM 2, Rab-3-interacting Protein 3, KIAA0751, RAB3IP3, RIM2)
Product Gene Name
anti-RIMS2 antibody
Product Synonym Names
Anti -RIMS2, ID (Regulating Synaptic Membrane Exocytosis Protein 2, Rab3-interacting Molecule 2, RIM 2, Rab-3-interacting Protein 3, KIAA0751, RAB3IP3, RIM2)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human RIMS2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
160,403 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (104512426..105266656). Location: 8q22.3
OMIM
606630
3D Structure
ModBase 3D Structure for Q9UQ26
Immunogen
Human RIMS2

Product Categories/Family for anti-RIMS2 antibody

Antibodies; Abs to Neuroscience
Applications Tested/Suitable for anti-RIMS2 antibody
Immunohistochemistry (IHC)
Application Notes for anti-RIMS2 antibody
Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-RIMS2 antibody

Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-RIMS2 Polyclonal Antibody – Cat# MBS647404

Immunohistochemistry (IHC) of anti-RIMS2 antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-RIMS2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647404

Other Notes

Small volumes of anti-RIMS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RIMS2 purchase

MBS647404 is an antibody targeting RIMS2. Also known as RIMS2, ID (Regulating Synaptic Membrane Exocytosis Protein 2, Rab3-interacting Molecule 2, RIM 2, Rab-3-interacting Protein 3, KIAA0751, RAB3IP3, RIM2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RIMS2. It may not necessarily be applicable to this product.

NCBI GI #
544583514
NCBI GeneID
9699
NCBI Accession #
NP_001269811.1
UniProt Primary Accession #
Q9UQ26
UniProt Secondary Accession #
O43413; Q86XL9; Q8IWV9; Q8IWW1; B3KX91; F8WD47
UniProt Related Accession #
Q9UQ26
GenBank Nucleotide #
NM_001282882.1
NCBI Official Full Name
regulating synaptic membrane exocytosis protein 2 isoform d
NCBI Official Synonym Full Names
regulating synaptic membrane exocytosis 2
NCBI Official Symbol
RIMS2
NCBI Official Synonym Symbols
OBOE; RIM2; RAB3IP3
UniProt Protein Name
Regulating synaptic membrane exocytosis protein 2
UniProt Synonym Protein Names
Rab-3-interacting molecule 2; RIM 2; Rab-3-interacting protein 3
Protein Family
Regulating synaptic membrane exocytosis protein
UniProt Gene Name
RIMS2
UniProt Synonym Gene Names
KIAA0751; RAB3IP3; RIM2; RIM 2
UniProt Entry Name
RIMS2_HUMAN
NCBI Protein Information
regulating synaptic membrane exocytosis protein 2; RIM 2; nuclear protein; RAB3 interacting protein 3; rab-3-interacting protein 3; rab3-interacting molecule 2; rab-3-interacting molecule 2; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein

UniProt Comments for RIMS2

Function: Rab effector involved in exocytosis. May act as scaffold protein.

Subunit structure: Interacts with RAB3A and RAB3B that have been activated by GTP-binding. Interacts with RAB3C, RAB3D and RAB26. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2

By similarity.

Subcellular location: Cell membrane; Peripheral membrane protein

By similarity. Cell junction › synapse

By similarity. Cell junction › synapse › presynaptic cell membrane; Peripheral membrane protein

By similarity.

Sequence similarities: Contains 2 C2 domains.Contains 1 FYVE-type zinc finger.Contains 1 PDZ (DHR) domain.Contains 1 RabBD (Rab-binding) domain.

Sequence caution: The sequence BAA34471.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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Research Articles on RIMS2

1. Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RIMS2 antibody

 Reference Product  PubMed Publications
 RIM2 antibody  >5 publications with RIMS2 and RIM2
 RPH3AL antibody  >1 publications with RIMS2 and RPH3AL
 RAPGEF4 antibody  >1 publications with RIMS2 and RAPGEF4
 RAB3A antibody  >1 publications with RIMS2 and RAB3A

Pathways associated with anti-RIMS2 antibody

 Products by Pathway  Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram

Diseases associated with anti-RIMS2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with RIMS2 and Neoplasms
 Fever Antibodies  >1 publications with RIMS2 and Fever

Organs/Tissues associated with anti-RIMS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with RIMS2 and Brain
 Pancreas Antibodies  >2 publications with RIMS2 and Pancreas
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