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Jhdm2a (KDM3A) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647407

KDM3A is a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
JHDM2a (KDM3A), Polyclonal Antibody
Full Product Name
JHDM2a, CT (KDM3A, JHDM2A, JMJD1, JMJD1A, KIAA0742, TSGA, Lysine-specific demethylase 3A, JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A)
Product Gene Name
anti-KDM3A antibody
Product Synonym Names
Anti -JHDM2a, CT (KDM3A, JHDM2A, JMJD1, JMJD1A, KIAA0742, TSGA, Lysine-specific demethylase 3A, JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
147,341 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (86668271..86719839). Location: 2p11.2
OMIM
611512
3D Structure
ModBase 3D Structure for Q9Y4C1
Immunogen
JHDM2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 983-1017 amino acids from the C-terminal region of human JHDM2a.

Product Categories/Family for anti-KDM3A antibody

Antibodies; Abs to Histones
Applications Tested/Suitable for anti-KDM3A antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KDM3A antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-KDM3A antibody

JHDM2a Antibody (C-term) western blot analysis in uterus tumor cell line lysates (35ug/lane).This demonstrates the JHDM2a antibody detected the JHDM2a protein (arrow).
Rabbit Anti-KDM3A Polyclonal Antibody – Cat# MBS647407

Immunohistochemistry (IHC) of anti-KDM3A antibody

JHDM2a Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of JHDM2a Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-KDM3A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647407

Other Notes

Small volumes of anti-KDM3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KDM3A purchase

MBS647407 is an antibody targeting KDM3A. Also known as JHDM2a, CT (KDM3A, JHDM2A, JMJD1, JMJD1A, KIAA0742, TSGA, Lysine-specific demethylase 3A, JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KDM3A. It may not necessarily be applicable to this product.

NCBI GI #
225000276
NCBI GeneID
55818
NCBI Accession #
AAI72547.1
UniProt Primary Accession #
Q9Y4C1
UniProt Secondary Accession #
Q53S72; Q68D47; Q68UT9; Q6N050; Q8IY08; D6W5M3
UniProt Related Accession #
Q9Y4C1
NCBI Official Full Name
Jumonji domain containing 1A
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 3A
NCBI Official Symbol
KDM3A
NCBI Official Synonym Symbols
TSGA; JMJD1; JHDM2A; JHMD2A; JMJD1A
UniProt Protein Name
Lysine-specific demethylase 3A
UniProt Synonym Protein Names
JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A
Protein Family
Lysine-specific demethylase
UniProt Gene Name
KDM3A
UniProt Synonym Gene Names
JHDM2A; JMJD1; JMJD1A; KIAA0742; TSGA
UniProt Entry Name
KDM3A_HUMAN
NCBI Protein Information
lysine-specific demethylase 3A; testis-specific protein A; jumonji domain containing 1; jumonji domain containing 1A; jumonji domain-containing protein 1A; jumonji C domain-containing histone demethylase 2A; jmjC domain-containing histone demethylation protein 2A

NCBI Summary for KDM3A

This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

UniProt Comments for KDM3A

Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. Ref.5

Cofactor: Binds 1 Fe2+ ion per subunit. Ref.5

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity. Note: Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa

By similarity.

Domain: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. Ref.5Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors

By similarity. Ref.5

Sequence similarities: Belongs to the JHDM2 histone demethylase family.Contains 1 JmjC domain.

Sequence caution: The sequence BAA34462.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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Research Articles on KDM3A

1. Data indicate that JMJD1A gene silencing abrogated the hypoxia-induced adrenomedullin (ADM) expression and inhibited HepG2 and Hep3B cell growth.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KDM3A antibody

 Reference Product  PubMed Publications
 HIF1A antibody  >8 publications with KDM3A and HIF1A
 TNP1 antibody  >3 publications with KDM3A and TNP1
 PRM1 antibody  >3 publications with KDM3A and PRM1
 PPARA antibody  >1 publications with KDM3A and PPARA
 UCP1 antibody  >1 publications with KDM3A and UCP1

Pathways associated with anti-KDM3A antibody

 Products by Pathway  Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with anti-KDM3A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with KDM3A and Neoplasms
 Lung Neoplasms Antibodies  >3 publications with KDM3A and Lung Neoplasms
 Liver Neoplasms Antibodies  >2 publications with KDM3A and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with KDM3A and Liver Diseases
 Neoplasm Invasiveness Antibodies  >2 publications with KDM3A and Neoplasm Invasiveness
 Carcinoma, Hepatocellular Antibodies  >2 publications with KDM3A and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >2 publications with KDM3A and Disease Models, Animal
 Kidney Diseases Antibodies  >2 publications with KDM3A and Kidney Diseases
 Inflammation Antibodies  >1 publications with KDM3A and Inflammation
 Anemia Antibodies  >1 publications with KDM3A and Anemia

Organs/Tissues associated with anti-KDM3A antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4 publications with KDM3A and Muscle
 Vascular Antibodies  >4 publications with KDM3A and Vascular
 Testis Antibodies  >4 publications with KDM3A and Testis
 Lung Antibodies  >3 publications with KDM3A and Lung
 Kidney Antibodies  >3 publications with KDM3A and Kidney
 Liver Antibodies  >3 publications with KDM3A and Liver
 Blood Antibodies  >3 publications with KDM3A and Blood
 Embryonic Tissue Antibodies  >2 publications with KDM3A and Embryonic Tissue
 Prostate Antibodies  >2 publications with KDM3A and Prostate
 Skin Antibodies  >1 publications with KDM3A and Skin
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