Rabbit Anti-TAF1B Polyclonal Antibody – Cat# MBS647445

Western Blot analysis of TAF1B expression in transfected 293T cell line by TAF1B polyclonal antibody. Lane 1: TAF1B transfected lysate (68.8kD). Lane 2: Non-transfected lysate.

TAF1B Antibody – Rabbit Polyclonal

Name: TAF1B Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647445
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647445

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I… More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TAF1B, Polyclonal Antibody

Full Product Name

TAF1B (TATA Box-binding Protein-associated Factor RNA Polymerase I Subunit B, RNA Polymerase I-specific TBP-associated Factor 63 kDa, TAFI63, TATA Box-binding Protein-associated Factor 1B, TBP-associated Factor 1B, Transcription Initiation Factor SL1/TIF-

Product Gene Name

anti-TAF1B antibody

Product Synonym Names

Anti -TAF1B (TATA Box-binding Protein-associated Factor RNA Polymerase I Subunit B, RNA Polymerase I-specific TBP-associated Factor 63 kDa, TAFI63, TATA Box-binding Protein-associated Factor 1B, TBP-associated Factor 1B, Transcription Initiation Factor SL1/TIF-

Immunogen Sequence

MDLEESEEFK ERCTQCAAVS WGLTDEGKYY CTSCHNVTER YQEVTNTDLI PNTQIKALNR GLKKKNNTEK GWDWYVCEGF QYILYQQAEA LKNLGVGPEL KNDVLHNFWK RYLQKSKQAY CKNPVYTTGR KPTVLEDNLS HSDWASEPEL LSDVSCPPFL ESGAESQSDI HTRKPFPVSK ASQSETSVCS GSLDGVEYSQ RKEKGIVKMT MPQTLAFCYL SLLWQREAIT LSDLLRFVEE DHIPYINAFQ HFPEQMKLYG RDRGIFGIES WPDYEDIYKK TIEVGTFLDL PRFPDITEDC YLHPNILCMK YLMEVNLPDE MHSLTCHVVK MTGMGEVDFL TFDPIAKMAK AVKYDVQAVA IIVVVLKLLF LLDDSFEWSL SNLAEKHNEK NKKDKPWFDF RKWYQIMKKA FDEKKQKWEE ARAKYLWKSE KPLYYSFVDK PVAYKKREMV VNLQKQFSTL VDSTATAGKK SPSSFQFNWT EEDTDRTCFH GHSLQGVLKE KGQSLLTKNS LYWLSTQKFC RCYCTHVTTY EESNYSLSYQ FILNLFSFLL RIKTSLLHEE VSLVEKKLFE KKYSVKRKKS RSKKVRRH

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human TAF1B.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

68,832 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (9983571..10074545). Location: 2p25

OMIM

604904

3D Structure

ModBase 3D Structure for Q53T94

Immunogen

Full length human TAF1B, aa1-588 (AAH18137.1).

Product Categories/Family for anti-TAF1B antibody

Antibodies; Abs to Enzymes; Polymerase

Applications Tested/Suitable for anti-TAF1B antibody

Western Blot (WB)

Application Notes for anti-TAF1B antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-TAF1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAF1B purchase

MBS647445 is an antibody targeting TAF1B. Also known as TAF1B (TATA Box-binding Protein-associated Factor RNA Polymerase I Subunit B, RNA Polymerase I-specific TBP-associated Factor 63 kDa, TAFI63, TATA Box-binding Protein-associated Factor 1B, TBP-associated Factor 1B, Transcription Initiation Factor SL1/TIF-. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TAF1B. It may not necessarily be applicable to this product.

NCBI GI #

205360987

NCBI GeneID

9014

NCBI Accession #

NP_005671.2

UniProt Primary Accession #

Q53T94

UniProt Secondary Accession #

Q15574; Q8WVC3; B4DI42; F8WD72

UniProt Related Accession #

Q53T94

GenBank Nucleotide #

NM_005680.2

NCBI Official Full Name

TATA box-binding protein-associated factor RNA polymerase I subunit B

NCBI Official Synonym Full Names

TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa

NCBI Official Symbol

TAF1B

NCBI Official Synonym Symbols

SL1; RAF1B; RAFI63; TAFI63; MGC:9349

UniProt Protein Name

TATA box-binding protein-associated factor RNA polymerase I subunit B

UniProt Synonym Protein Names

RNA polymerase I-specific TBP-associated factor 63 kDa; TAFI63; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B

Protein Family

Transcription initiation factor

UniProt Gene Name

TAF1B

UniProt Synonym Gene Names

TAFI63

UniProt Entry Name

TAF1B_HUMAN

NCBI Protein Information

TATA box-binding protein-associated factor RNA polymerase I subunit B; SL1, 63kD subunit; TBP-associated factor 1B; TATA box-binding protein-associated factor 1B; transcription initiation factor SL1/TIF-IB subunit B; RNA polymerase I-specific TBP-associated factor 63 kDa

NCBI Summary for TAF1B

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. [provided by RefSeq, Jul 2008]

UniProt Comments for TAF1B

Function: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Ref.1 Ref.5 Ref.6 Ref.9 Ref.11 Ref.12

Subunit structure: Interacts with FLNA (via N-terminus)

By similarity. Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3. Ref.1 Ref.8

Subcellular location: Nucleus › nucleolus.

Domain: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (Ref.11 and Ref.12).

Sequence similarities: Belongs to the RRN7/TAF1B family.Contains 1 RRN7-type zinc finger.

Sequence caution: The sequence AAA62863.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Research Articles on TAF1B

1. TAF1B, a subunit of SL1, is structurally related to TFIIB/TFIIB-like proteins; SL1, essential for Pol I recruitment to rRNA gene promoter, also has an essential postpolymerase recruitment role, operating through TAF1B

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TAF1B antibody

Reference Product	PubMed Publications
TBP antibody	>11 publications with TAF1B and TBP
TAF1C antibody	>5 publications with TAF1B and TAF1C
TAF1A antibody	>5 publications with TAF1B and TAF1A

Pathways associated with anti-TAF1B antibody

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
RNA Polymerase I Chain Elongation Pathway antibodies	RNA Polymerase I Chain Elongation Pathway Diagram
RNA Polymerase I Promoter Clearance Pathway antibodies	RNA Polymerase I Promoter Clearance Pathway Diagram
RNA Polymerase I Promoter Escape Pathway antibodies	RNA Polymerase I Promoter Escape Pathway Diagram
RNA Polymerase I Transcription Pathway antibodies	RNA Polymerase I Transcription Pathway Diagram
RNA Polymerase I Transcription Initiation Pathway antibodies	RNA Polymerase I Transcription Initiation Pathway Diagram
RNA Polymerase I Transcription Termination Pathway antibodies	RNA Polymerase I Transcription Termination Pathway Diagram
RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies	RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram

Diseases associated with anti-TAF1B antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with TAF1B and Neoplasms
Adenoma Antibodies	>2 publications with TAF1B and Adenoma
Hepatitis Antibodies	>1 publications with TAF1B and Hepatitis
Cell Transformation, Neoplastic Antibodies	>1 publications with TAF1B and Cell Transformation, Neoplastic
Chromosome Aberrations Antibodies	>1 publications with TAF1B and Chromosome Aberrations

Organs/Tissues associated with anti-TAF1B antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>1 publications with TAF1B and Muscle
Uncharacterized Tissue Antibodies	>1 publications with TAF1B and Uncharacterized Tissue