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CDK2AP1 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647456

The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase… More details

$880 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDK2AP1, Polyclonal Antibody
Full Product Name
CDK2AP1 (Cyclin-dependent Kinase 2-associated Protein 1, CDK2-associated Protein 1, Deleted in Oral Cancer 1, DOC-1, Putative Oral Cancer Suppressor, CDKAP1, DOC1)
Product Gene Name
Product Synonym Names
Anti -CDK2AP1 (Cyclin-dependent Kinase 2-associated Protein 1, CDK2-associated Protein 1, Deleted in Oral Cancer 1, DOC-1, Putative Oral Cancer Suppressor, CDKAP1, DOC1)
Immunogen Sequence
MSYKPNLAAH MPAAALNAAG SVHSPSTSMA TSSQYRQLLS DYGPPSLGYT QGTGNSQVPQ SKYAELLAII EELGKEIRPT YAGSKSAMER LKRGIIHARG LVRECLAETE RNARS
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CDK2AP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
12,365 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (123745517..123756863, complement). Location: 12q24.31
OMIM
602198
3D Structure
ModBase 3D Structure for O14519
Immunogen
Full length human CDK2AP1, aa1-115 (AAH34717.1).
Applications Tested/Suitable for anti-CDK2AP1 antibody
Western Blot (WB)
Application Notes for anti-CDK2AP1 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-CDK2AP1 antibody

Western Blot analysis of CDK2AP1 expression in transfected 293T cell line by CDK2AP1 polyclonal antibody. Lane 1: CDK2AP1 transfected lysate (12.4kD). Lane 2: Non-transfected lysate.
Mouse Anti-CDK2AP1 Polyclonal Antibody – Cat# MBS647456

Other Notes

Small volumes of anti-CDK2AP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK2AP1 purchase

MBS647456 is an antibody targeting CDK2AP1. Also known as CDK2AP1 (Cyclin-dependent Kinase 2-associated Protein 1, CDK2-associated Protein 1, Deleted in Oral Cancer 1, DOC-1, Putative Oral Cancer Suppressor, CDKAP1, DOC1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CDK2AP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cyclin-dependent kinase 2-associated protein 1 isoform 2
NCBI Official Synonym Full Names
cyclin-dependent kinase 2 associated protein 1
NCBI Official Symbol
CDK2AP1
NCBI Official Synonym Symbols
DOC1; ST19; DORC1; doc-1; p12DOC-1
UniProt Protein Name
Cyclin-dependent kinase 2-associated protein 1
UniProt Synonym Protein Names
Deleted in oral cancer 1; DOC-1; Putative oral cancer suppressor
UniProt Gene Name
CDK2AP1
UniProt Synonym Gene Names
CDKAP1; DOC1; CDK2-associated protein 1; DOC-1
UniProt Entry Name
CDKA1_HUMAN
NCBI Protein Information
cyclin-dependent kinase 2-associated protein 1; Deleted in oral cancer-1; deleted in oral cancer 1; CDK2-associated protein 1; putative oral cancer suppressor

NCBI Summary for CDK2AP1

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
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UniProt Comments for CDK2AP1

Function: specific inhibitor of the cell-cycle kinase CDK2

By similarity.

Subunit structure: Homodimer. Interacts with monomeric unphosphorylated CDK2. Ref.6

Post-translational modification: Phosphorylated in vitro by IKBKE at Ser-46. Ref.6

Sequence similarities: Belongs to the CDK2AP family.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDK2AP1 antibody

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