Rabbit Anti-SERPINB8 Polyclonal Antibody – Cat# MBS647518

SERPINB8 Antibody – Rabbit Polyclonal

Name: SERPINB8 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647518
Price: 585 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647518

High molecular weight serine protease inhibitors (serpins) are large superfamily of proteins, which bind to and inactivate serine proteinases. In 1995 Sprecher et al. cloned 2 novel serpins, termed PI8 and PI9, from human placenta cDNA library. Sequencing… More details

$585 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SERPINB8, Polyclonal Antibody

Full Product Name

SERPINB8 (Serine/Cysteine Proteinase Inhibitor, Clade B, Member 8, NK10, PI8)

Product Gene Name

anti-SERPINB8 antibody

Product Synonym Names

Anti -SERPINB8 (Serine/Cysteine Proteinase Inhibitor, Clade B, Member 8, NK10, PI8)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 1% BSA, 0.02% thimerosal, 30% glycerol.

Purity/Purification

Affinity Purified
Purified by affinity chromatography.

Specificity

Recognizes human PI-8 at ~40-45kD.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

42,767 Da

Chromosome Location

Chromosome: 18; NC_000018.9 (61637263..61656608). Location: 18q22.1

OMIM

601697

3D Structure

ModBase 3D Structure for P50452

Immunogen

Synthetic peptide corresponding to aa10 from human PI-8.

Product Categories/Family for anti-SERPINB8 antibody

Antibodies; Abs to Protease Inhibitors

Applications Tested/Suitable for anti-SERPINB8 antibody

Western Blot (WB)

Application Notes for anti-SERPINB8 antibody

Suitable for use in Western Blot.
Dilution: Western Blot: 0.5-4ug/ml

Other Notes

Small volumes of anti-SERPINB8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINB8 purchase

MBS647518 is an antibody targeting SERPINB8. Also known as SERPINB8 (Serine/Cysteine Proteinase Inhibitor, Clade B, Member 8, NK10, PI8). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINB8. It may not necessarily be applicable to this product.

NCBI GI #

451770404

NCBI GeneID

5271

NCBI Accession #

NP_001263419.1

UniProt Primary Accession #

P50452

UniProt Secondary Accession #

Q7Z2V6; Q8N178

UniProt Related Accession #

P50452

GenBank Nucleotide #

NM_001276490.1

NCBI Official Full Name

serpin B8 isoform c

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade B (ovalbumin), member 8

NCBI Official Symbol

SERPINB8

NCBI Official Synonym Symbols

PI8; CAP2

UniProt Protein Name

Serpin B8

UniProt Synonym Protein Names

Cytoplasmic antiproteinase 2; CAP-2; CAP2; Peptidase inhibitor 8

Protein Family

Serpin

UniProt Gene Name

SERPINB8

UniProt Synonym Gene Names

PI8; CAP-2; CAP2; PI-8

UniProt Entry Name

SPB8_HUMAN

NCBI Protein Information

serpin B8; PI-8; peptidase inhibitor 8; cytoplasmic antiproteinase 2; protease inhibitor 8 (ovalbumin type); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8

NCBI Summary for SERPINB8

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

UniProt Comments for SERPINB8

Subcellular location: Cytoplasm.

Sequence similarities: Belongs to the serpin family. Ov-serpin subfamily.

Research Articles on SERPINB8

1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SERPINB8 antibody

Reference Product	PubMed Publications
FURIN antibody	>4 publications with SERPINB8 and FURIN

Pathways associated with anti-SERPINB8 antibody

Products by Pathway	Pathway Diagram
Dissolution Of Fibrin Clot Pathway antibodies	Dissolution Of Fibrin Clot Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with anti-SERPINB8 antibody

Disease Name	Pubmed Publications
Psoriasis Antibodies	>4 publications with SERPINB8 and Psoriasis
Inflammation Antibodies	>3 publications with SERPINB8 and Inflammation
Neoplasms Antibodies	>2 publications with SERPINB8 and Neoplasms
Cardiovascular Diseases Antibodies	>1 publications with SERPINB8 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>1 publications with SERPINB8 and Breast Neoplasms
Prostatic Neoplasms Antibodies	>1 publications with SERPINB8 and Prostatic Neoplasms
Atherosclerosis Antibodies	>1 publications with SERPINB8 and Atherosclerosis
Necrosis Antibodies	>1 publications with SERPINB8 and Necrosis

Organs/Tissues associated with anti-SERPINB8 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>4 publications with SERPINB8 and Skin
Kidney Antibodies	>3 publications with SERPINB8 and Kidney
Pancreas Antibodies	>2 publications with SERPINB8 and Pancreas
Intestine Antibodies	>1 publications with SERPINB8 and Intestine
Brain Antibodies	>1 publications with SERPINB8 and Brain
Placenta Antibodies	>1 publications with SERPINB8 and Placenta
Embryonic Tissue Antibodies	>1 publications with SERPINB8 and Embryonic Tissue
Mouth Antibodies	>1 publications with SERPINB8 and Mouth
Heart Antibodies	>1 publications with SERPINB8 and Heart
Pharynx Antibodies	>1 publications with SERPINB8 and Pharynx