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FBXO9 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647681

This gene encodes a member of the F-box protein family which is characterized by an approximately 40aa motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FBXO9, Polyclonal Antibody
Full Product Name
FBXO9 (FBX9, VCIA1, F-box Only Protein 9, Cross-immune Reaction Antigen 1, Renal Carcinoma Antigen NY-REN-57, dJ341E18.2, DKFZp434C0118, KIAA0936)
Product Gene Name
anti-FBXO9 antibody
Product Synonym Names
Anti -FBXO9 (FBX9, VCIA1, F-box Only Protein 9, Cross-immune Reaction Antigen 1, Renal Carcinoma Antigen NY-REN-57, dJ341E18.2, DKFZp434C0118, KIAA0936)
Immunogen Sequence
MAEAEEDCHS DTVRADDDEE NESPAETDLQ AQLQMFRAQW MFELAPGVSS SNLENRPCRA ARGSLQKTSA DTKGKQEQAK EEKARELFLK AVEEEQNGAL YEAIKFYRRA MQLVPDIEFK ITYTRSPDGD GVGNSYIEDN DDDSKMADLL SYFQQQLTFQ ESVLKLCQPE LESSQIHISV LPMEVLMYIF RWVVSSDLDL RSLEQLSLVC RGFYICARDP EIWRLACLKV WGRSCIKLVP YTSWREMFLE RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYI RFFPDGHVMM LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK VFAVITKKKE EKPLDYKYRY FRRVPVQEAD QSFHVGLQLC SSGHQRFNKL IWIHHSCHIT YKSTGETAVS AFEIDKMYTP LFFARVRSYT AFSERPL
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human FBXO9.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
50,817 Da
Chromosome Location
Chromosome: 23; AC_000180.1 (25030303..25051794). Location: chromosome: 23
3D Structure
ModBase 3D Structure for Q3ZBT2
Immunogen
Full length human FBXO9, aa1-437 (NP_258441.1).

Product Categories/Family for anti-FBXO9 antibody

Antibodies; Abs to Ubiquitin Ligases
Applications Tested/Suitable for anti-FBXO9 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-FBXO9 antibody
Suitable for use in Western Blot and Immunofluorescence.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-FBXO9 antibody

Western Blot analysis of FBXO9 expression in transfected 293T cell line by FBXO9 polyclonal antibody. Lane 1: FBXO9 transfected lysate (48.07kD). Lane 2: Non-transfected lysate.
Mouse Anti-FBXO9 Polyclonal Antibody – Cat# MBS647681

Immunofluorescence (IF) of anti-FBXO9 antibody

Immunofluorescence of purified antibody to FBXO9 on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-FBXO9 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS647681

Other Notes

Small volumes of anti-FBXO9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBXO9 purchase

MBS647681 is an antibody targeting FBXO9. Also known as FBXO9 (FBX9, VCIA1, F-box Only Protein 9, Cross-immune Reaction Antigen 1, Renal Carcinoma Antigen NY-REN-57, dJ341E18.2, DKFZp434C0118, KIAA0936). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FBXO9. It may not necessarily be applicable to this product.

NCBI GI #
77735771
NCBI GeneID
511798
NCBI Accession #
NP_001029584.1
UniProt Primary Accession #
Q3ZBT2
UniProt Secondary Accession #
F1MVQ0
UniProt Related Accession #
Q3ZBT2
GenBank Nucleotide #
NM_001034412.2
NCBI Official Full Name
F-box only protein 9
NCBI Official Symbol
FBXO9
UniProt Protein Name
F-box only protein 9
Protein Family
F-box only protein
UniProt Gene Name
FBXO9
UniProt Entry Name
FBX9_BOVIN
NCBI Protein Information
F-box only protein 9

UniProt Comments for FBXO9

Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1

By similarity.

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2

By similarity.

Subcellular location: Cytoplasm

By similarity.

Sequence similarities: Contains 1 F-box domain.Contains 1 TPR repeat.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FBXO9 antibody

 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >1 publications with FBXO9 and Muscular Diseases
 Neoplasms Antibodies  >1 publications with FBXO9 and Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with FBXO9 and Cardiovascular Diseases

Organs/Tissues associated with anti-FBXO9 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >1 publications with FBXO9 and Embryonic Tissue
 Muscle Antibodies  >1 publications with FBXO9 and Muscle
 Kidney Antibodies  >1 publications with FBXO9 and Kidney
 Liver Antibodies  >1 publications with FBXO9 and Liver
 Uncharacterized Tissue Antibodies  >1 publications with FBXO9 and Uncharacterized Tissue
 Brain Antibodies  >1 publications with FBXO9 and Brain
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