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F2RL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647692

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
F2RL2, Polyclonal Antibody
Full Product Name
F2RL2, NT (F2RL2, PAR3, Proteinase-activated receptor 3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2)
Product Gene Name
anti-F2RL2 antibody
Product Synonym Names
Anti -F2RL2, NT (F2RL2, PAR3, Proteinase-activated receptor 3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,508 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (75911307..75919259, complement). Location: 5q13
OMIM
601919
3D Structure
ModBase 3D Structure for O00254
Immunogen
F2RL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-50 amino acids from the N-terminal region of human F2RL2.

Product Categories/Family for anti-F2RL2 antibody

Antibodies; Abs to Coagulation Factors
Applications Tested/Suitable for anti-F2RL2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-F2RL2 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-F2RL2 antibody

F2RL2 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the F2RL2 antibody detected the F2RL2 protein (arrow).
Rabbit Anti-F2RL2 Polyclonal Antibody – Cat# MBS647692

Immunohistochemistry (IHC) of anti-F2RL2 antibody

F2RL2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of F2RL2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-F2RL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647692

Other Notes

Small volumes of anti-F2RL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for F2RL2 purchase

MBS647692 is an antibody targeting F2RL2. Also known as F2RL2, NT (F2RL2, PAR3, Proteinase-activated receptor 3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for F2RL2. It may not necessarily be applicable to this product.

NCBI GI #
66267325
NCBI GeneID
2151
NCBI Accession #
AAH95499.1
UniProt Primary Accession #
O00254
UniProt Secondary Accession #
Q52M68; Q7Z3W3; B2R754; B4DQ13
UniProt Related Accession #
O00254
NCBI Official Full Name
F2RL2 protein, partial
NCBI Official Synonym Full Names
coagulation factor II (thrombin) receptor-like 2
NCBI Official Symbol
F2RL2
NCBI Official Synonym Symbols
PAR3; PAR-3
UniProt Protein Name
Proteinase-activated receptor 3
UniProt Synonym Protein Names
Coagulation factor II receptor-like 2; Thrombin receptor-like 2
Protein Family
Proteinase-activated receptor
UniProt Gene Name
F2RL2
UniProt Synonym Gene Names
PAR3; PAR-3
UniProt Entry Name
PAR3_HUMAN
NCBI Protein Information
proteinase-activated receptor 3; thrombin receptor-like 2; protease-activated receptor 3; proteinase-activated receptor-3; Coagulation factor II receptor-like 2 (protease-actovated receptor 3)

NCBI Summary for F2RL2

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
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UniProt Comments for F2RL2

Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. Ref.9

Subunit structure: Interacts with INSC/inscuteable and probably GPSM2. Ref.10

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut. Ref.8

Post-translational modification: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Sequence caution: The sequence CAD97628.1 differs from that shown. Reason: Frameshift at position 374.
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Research Articles on F2RL2

1. PAR-3 receptors interact with thrombin and increase heme oxygenase-1 expression in synovial fibroblasts.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-F2RL2 antibody

 Reference Product  PubMed Publications
 F2RL1 antibody  >1 publications with F2RL2 and F2RL1
 F2RL3 antibody  >1 publications with F2RL2 and F2RL3

Pathways associated with anti-F2RL2 antibody

 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram

Diseases associated with anti-F2RL2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with F2RL2 and Inflammation

Organs/Tissues associated with anti-F2RL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1 publications with F2RL2 and Vascular
 Muscle Antibodies  >1 publications with F2RL2 and Muscle
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