Mouse Anti-HFE2 Polyclonal Antibody – Cat# MBS647710

Western Blot analysis of HFE2 expression in transfected 293T cell line by HFE2 polyclonal antibody. Lane 1: HFE2 transfected lysate (34.43kD). Lane 2: Non-transfected lysate.

HFE2 Antibody – Mouse Polyclonal

Name: HFE2 Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647710
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647710

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively… More details

$880 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HFE2, Polyclonal Antibody

Full Product Name

HFE2 (Hemojuvelin, Hemochromatosis Type 2 Protein, RGM Domain Family Member C, HJV, RGMC, MGC23953)

Product Gene Name

anti-HFE2 antibody

Product Synonym Names

Anti -HFE2 (Hemojuvelin, Hemochromatosis Type 2 Protein, RGM Domain Family Member C, HJV, RGMC, MGC23953)

Immunogen Sequence

MIQHNCSRQG PTAPPPPRGP ALPGAGSGLP APDPCDYEGR FSRLHGRPPG FLHCASFGDP HVRSFHHHFH TCRVQGAWPL LDNDFLFVQA TSSPMALGAN ATATRKLTII FKNMQECIDQ KVYQAEVDNL PVAFEDGSIN GGDRPGGSSL SIQTANPGNH VEIQAAYIGT TIIIRQTAGQ LSFSIKVAED VAMAFSAEQD LQLCVGGCPP SQRLSRSERN RRGAITIDTA RRLCKEGLPV EDAYFHSCVF DVLISGDPNF TVAAQAALED ARAFLPDLEK LHLFPSDAGV PLSSATLLAP LLSGLFVLWL CIQ

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human HFE2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

45,080 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (145413191..145417545). Location: 1q21.1

OMIM

602390

3D Structure

ModBase 3D Structure for Q6ZVN8

Immunogen

Full length human HFE2, aa1-313 (NP_660320.3).

Product Categories/Family for anti-HFE2 antibody

Antibodies; Abs to Proteins

Applications Tested/Suitable for anti-HFE2 antibody

Western Blot (WB)

Application Notes for anti-HFE2 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-HFE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HFE2 purchase

MBS647710 is an antibody targeting HFE2. Also known as HFE2 (Hemojuvelin, Hemochromatosis Type 2 Protein, RGM Domain Family Member C, HJV, RGMC, MGC23953). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for HFE2. It may not necessarily be applicable to this product.

NCBI GI #

47458050

NCBI GeneID

148738

NCBI Accession #

NP_998817.1

UniProt Primary Accession #

Q6ZVN8

UniProt Secondary Accession #

Q2PQ63; Q6IMF6; Q8NAH2; Q8WVJ5; B1ALI7

UniProt Related Accession #

Q6ZVN8

GenBank Nucleotide #

NM_213652.3

NCBI Official Full Name

hemojuvelin isoform c

NCBI Official Synonym Full Names

hemochromatosis type 2 (juvenile)

NCBI Official Symbol

HFE2

NCBI Official Synonym Symbols

JH; HJV; RGMC; HFE2A

UniProt Protein Name

Hemojuvelin

UniProt Synonym Protein Names

Hemochromatosis type 2 protein; RGM domain family member C

Protein Family

Hemojuvelin

UniProt Gene Name

HFE2

UniProt Synonym Gene Names

HJV; RGMC

UniProt Entry Name

RGMC_HUMAN

NCBI Protein Information

hemojuvelin; haemojuvelin; RGM domain family member C; repulsive guidance molecule c; hemochromatosis type 2 protein

UniProt Comments for HFE2

Function: Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor

By similarity. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism

By similarity. May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin.

Subunit structure: Interacts with BMP2 and BMP4

By similarity. Interacts with BMPR1B. Interacts with TMPRSS6. Ref.7 Ref.8

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor

By similarity.

Tissue specificity: Adult and fetal liver, heart, and skeletal muscle. Ref.1

Involvement in disease: Hemochromatosis 2A (HFE2A) [MIM:602390]: A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.9 Ref.10 Ref.11

Sequence similarities: Belongs to the repulsive guidance molecule (RGM) family.

Research Articles on HFE2

1. Hemojuvelin and hepcidin affect iron metabolism and are elevated in kidney and heart allograft recipients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HFE2 antibody

Reference Product	PubMed Publications
HAMP antibody	>33 publications with HFE2 and HAMP
BMP2 antibody	>15 publications with HFE2 and BMP2
BMP4 antibody	>9 publications with HFE2 and BMP4
NEO1 antibody	>2 publications with HFE2 and NEO1
BMPR2 antibody	>1 publications with HFE2 and BMPR2
BMPR1A antibody	>1 publications with HFE2 and BMPR1A
SMAD5 antibody	>1 publications with HFE2 and SMAD5

Pathways associated with anti-HFE2 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
BMP Receptor Signaling Pathway antibodies	BMP Receptor Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Netrin-1 Signaling Pathway antibodies	Netrin-1 Signaling Pathway Diagram

Diseases associated with anti-HFE2 antibody

Disease Name	Pubmed Publications
Hemochromatosis Antibodies	>112 publications with HFE2 and Hemochromatosis
Anemia Antibodies	>28 publications with HFE2 and Anemia
Liver Diseases Antibodies	>21 publications with HFE2 and Liver Diseases
Inflammation Antibodies	>16 publications with HFE2 and Inflammation
Heart Diseases Antibodies	>6 publications with HFE2 and Heart Diseases
Neoplasms Antibodies	>5 publications with HFE2 and Neoplasms
Carcinoma, Hepatocellular Antibodies	>5 publications with HFE2 and Carcinoma, Hepatocellular
Disease Models, Animal Antibodies	>4 publications with HFE2 and Disease Models, Animal
Liver Neoplasms Antibodies	>4 publications with HFE2 and Liver Neoplasms
Necrosis Antibodies	>3 publications with HFE2 and Necrosis

Organs/Tissues associated with anti-HFE2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>86 publications with HFE2 and Liver
Blood Antibodies	>65 publications with HFE2 and Blood
Muscle Antibodies	>22 publications with HFE2 and Muscle
Heart Antibodies	>20 publications with HFE2 and Heart
Testis Antibodies	>2 publications with HFE2 and Testis
Nerve Antibodies	>1 publications with HFE2 and Nerve
Embryonic Tissue Antibodies	>1 publications with HFE2 and Embryonic Tissue