Rabbit Anti-SYT2 Polyclonal Antibody – Cat# MBS647833

SYT2 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SYT2 antibody detected the SYT2 protein (arrow).

SYT2 Antibody – Rabbit Polyclonal

Name: SYT2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647833
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647833

Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]). More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SYT2, Polyclonal Antibody

Full Product Name

SYT2, ID (SYT2, Synaptotagmin-2, Synaptotagmin II)

Product Gene Name

anti-SYT2 antibody

Product Synonym Names

Anti -SYT2, ID (SYT2, Synaptotagmin-2, Synaptotagmin II)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

46,872 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (202559724..202679551, complement). Location: 1q32.1

OMIM

600104

3D Structure

ModBase 3D Structure for Q8N9I0

Immunogen

SYT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-272 amino acids from the Central region of human SYT2.

Product Categories/Family for anti-SYT2 antibody

Antibodies; Abs to Syntaxin; Synaptotagmin; Synaptophysin

Applications Tested/Suitable for anti-SYT2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SYT2 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-SYT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SYT2 purchase

MBS647833 is an antibody targeting SYT2. Also known as SYT2, ID (SYT2, Synaptotagmin-2, Synaptotagmin II). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SYT2. It may not necessarily be applicable to this product.

NCBI GI #

211059429

NCBI GeneID

127833

NCBI Accession #

NP_001129976.1

UniProt Primary Accession #

Q8N9I0

UniProt Secondary Accession #

Q496K5; Q8NBE5

UniProt Related Accession #

Q8N9I0

GenBank Nucleotide #

NM_001136504.1

NCBI Official Full Name

synaptotagmin-2

NCBI Official Synonym Full Names

synaptotagmin II

NCBI Official Symbol

SYT2

NCBI Official Synonym Symbols

SytII

UniProt Protein Name

Synaptotagmin-2

UniProt Synonym Protein Names

Synaptotagmin II

Protein Family

Synaptotagmin

UniProt Gene Name

SYT2

UniProt Synonym Gene Names

SytII

UniProt Entry Name

SYT2_HUMAN

NCBI Protein Information

synaptotagmin-2; synaptotagmin 2

UniProt Comments for SYT2

Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone

By similarity.

Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains

By similarity.

Subunit structure: Homotetramer

Probable. Interacts with stonin 2

By similarity. Interacts with SCAMP5. Ref.3

Subcellular location: Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein

By similarity. Cytoplasmic vesicle › secretory vesicle › chromaffin granule membrane; Single-pass membrane protein

By similarity. Note: Synaptic vesicles and chromaffin granules

By similarity.

Domain: The first C2 domain mediates Ca2+-dependent phospholipid binding

By similarity.The second C2 domain mediates interaction with Stonin 2

By similarity.

Sequence similarities: Belongs to the synaptotagmin family.Contains 2 C2 domains.

Research Articles on SYT2

1. Human SytII is not an effective receptor for Botulinum neurotoxin D-C.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SYT2 antibody

Reference Product	PubMed Publications
SYT1 antibody	>31 publications with SYT2 and SYT1
STON2 antibody	>1 publications with SYT2 and STON2
WNK1 antibody	>1 publications with SYT2 and WNK1

Pathways associated with anti-SYT2 antibody

Products by Pathway	Pathway Diagram
Botulinum Neurotoxicity Pathway antibodies	Botulinum Neurotoxicity Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Translocation Of BoNT Light Chain Pathway antibodies	Translocation Of BoNT Light Chain Pathway Diagram

Diseases associated with anti-SYT2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>6 publications with SYT2 and Nervous System Diseases
Chorea Antibodies	>1 publications with SYT2 and Chorea
Necrosis Antibodies	>1 publications with SYT2 and Necrosis
Immune System Diseases Antibodies	>1 publications with SYT2 and Immune System Diseases
Memory Disorders Antibodies	>1 publications with SYT2 and Memory Disorders

Organs/Tissues associated with anti-SYT2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>34 publications with SYT2 and Brain
Blood Antibodies	>4 publications with SYT2 and Blood
Embryonic Tissue Antibodies	>3 publications with SYT2 and Embryonic Tissue
Eye Antibodies	>3 publications with SYT2 and Eye
Adrenal Gland Antibodies	>1 publications with SYT2 and Adrenal Gland
Ganglia Antibodies	>1 publications with SYT2 and Ganglia
Larynx Antibodies	>1 publications with SYT2 and Larynx
Kidney Antibodies	>1 publications with SYT2 and Kidney