Clostridium Botulinum D Toxoid, Light Chain Antibody – Mouse Monoclonal

BoNT-D Light is a 50-55kD member of the peptidase M27 family of molecules. It is the product of Clostridium botulinum, and inhibits acetylcholine release from neuromuscular junctions. This is accomplished by toxin internalization with subsequent cleavage of synaptobrevin, thus blocking synaptic vesicle fusion with the presynaptic membrane. Notably, BoNT-D is not toxic to human cells. BoNT/D precursor is 1276aa in length. Following internalization and precursor proteolytic cleavage, it assumes a mature form that shows a disulfide-linked 442aa light chain/enzyme N-terminus, and a 834aa heavy chain/receptor-binding C-terminus. The 100kD heavy chain creates a channel within the endosome that allows for redox rupture of the disulfide bond and entry of the light chain into the cytosol. Covalent attachment of cargo molecules to the N-terminus is used to transport molecules into the cytosol. The D light chain shares less that 50% aa identity with the other botulinum serotype light chains.

Small volumes of anti-Clostridium botulinum D Toxoid, Light Chain antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS647866 is an antibody targeting Clostridium botulinum D Toxoid, Light Chain. Also known as Clostridium botulinum D Toxoid, Light Chain (BoNT/D, Bontoxilysin D, BOTD, Botulinum Neurotoxin Type D). Host: Mouse.