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Gonadotropin-Releasing Hormone (GRH) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6478736

MBS6478736 is an antibody targeting GRH. Also known as Gonadotropin-releasing Hormone, NT (GnRH, GRH, Gonadotrophin Releasing Hormone 1, GNRH1, GnRH-I, Gonadoliberin I, Gonadoliberin-1, Gonadorelin, Luliberin I, Luteinizing Hormorne Releasing Hormone, LHRH,… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gonadotropin-releasing Hormone (GRH), Polyclonal Antibody
Full Product Name
Gonadotropin-releasing Hormone, NT (GnRH, GRH, Gonadotrophin Releasing Hormone 1, GNRH1, GnRH-I, Gonadoliberin I, Gonadoliberin-1, Gonadorelin, Luliberin I, Luteinizing Hormorne Releasing Hormone, LHRH, LH-RH I, LNRH, Luteinizing Releasing Hormone, Progon
Product Gene Name
Product Synonym Names
Gonadotropin-releasing Hormone I; Gonadotropin-releasing Hormone 1 (Luteinizing-releasing Hormone); Luteinizing Hormone-releasing Hormone I
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human GNRH1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
10.38
OMIM
152760
3D Structure
ModBase 3D Structure for P01148
Immunogen
Synthetic peptide selected from the N-terminal region of human GNRH1 (KLH).
Conjugate
PE
Note
Preservative Free

Product Categories/Family for anti-GRH antibody

Applications Tested/Suitable for anti-GRH antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-GRH antibody
IHC: 1:10-1:50
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-GRH antibody

GNRH1 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the GNRH1 antibody detected the GNRH1 protein (arrow).
Rabbit Anti-GRH Polyclonal Antibody – Cat# MBS6478736

Immunohistochemistry (IHC) of anti-GRH antibody

GNRH1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GNRH1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-GRH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6478736

Product References and Citations for anti-GRH antibody

1. Hong, I.S., J. Clin. Endocrinol. Metab. 93(8), 3179-3185 (2008). 2. Baroncini, M., J. Neuroendocrinol. 19(9), 691-702 (2007). 3. Nikolics, K., Nature 316(6028), 511-517 (1985).

Other Notes

Small volumes of anti-GRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRH. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
progonadoliberin-1 isoform 1
NCBI Official Synonym Full Names
gonadotropin releasing hormone 1
NCBI Official Symbol
GNRH1
NCBI Official Synonym Symbols
GRH; GNRH; LHRH; LNRH
UniProt Protein Name
Progonadoliberin-1
UniProt Synonym Protein Names
Progonadoliberin ICleaved into the following 2 chains:Gonadoliberin-1Alternative name(s):Gonadoliberin I; Gonadorelin; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH I
Protein Family
UniProt Gene Name
GNRH1
UniProt Synonym Gene Names
GNRH; GRH; LHRH; GnRH-I; LH-RH I
UniProt Entry Name
GON1_HUMAN
NCBI Protein Information
progonadoliberin-1

NCBI Summary for GRH

This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]
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UniProt Comments for GRH

GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.

Protein type: Hormone; Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21-p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; luteinizing hormone-releasing factor activity

Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; negative regulation of apoptosis; response to corticosteroid stimulus

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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