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RPS6KC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647893

RPS6KC1 may be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RPS6KC1, Polyclonal Antibody
Full Product Name
RPS6KC1, NT (RPS6KC1, RPK118, Ribosomal protein S6 kinase delta-1, 52kD ribosomal protein S6 kinase, Ribosomal S6 kinase-like protein with two PSK domains 118kD protein, SPHK1-binding protein)
Product Gene Name
anti-RPS6KC1 antibody
Product Synonym Names
Anti -RPS6KC1, NT (RPS6KC1, RPK118, Ribosomal protein S6 kinase delta-1, 52kD ribosomal protein S6 kinase, Ribosomal S6 kinase-like protein with two PSK domains 118kD protein, SPHK1-binding protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
118,682 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (213224588..213446808). Location: 1q41
3D Structure
ModBase 3D Structure for Q96S38
Immunogen
RPS6KC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human RPS6KC1.

Product Categories/Family for anti-RPS6KC1 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-RPS6KC1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RPS6KC1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-RPS6KC1 antibody

RPS6KC1 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the RPS6KC1 antibody detected the RPS6KC1 protein (arrow).
Rabbit Anti-RPS6KC1 Polyclonal Antibody – Cat# MBS647893

Immunohistochemistry (IHC) of anti-RPS6KC1 antibody

RPS6KC1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RPS6KC1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-RPS6KC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS647893

Other Notes

Small volumes of anti-RPS6KC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RPS6KC1 purchase

MBS647893 is an antibody targeting RPS6KC1. Also known as RPS6KC1, NT (RPS6KC1, RPK118, Ribosomal protein S6 kinase delta-1, 52kD ribosomal protein S6 kinase, Ribosomal S6 kinase-like protein with two PSK domains 118kD protein, SPHK1-binding protein). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RPS6KC1. It may not necessarily be applicable to this product.

NCBI GI #
209915591
NCBI GeneID
26750
NCBI Accession #
NP_001129610.1
UniProt Primary Accession #
Q96S38
UniProt Secondary Accession #
Q8TDD3; Q9NSF4; Q9UL66; B1APS8; B3KVM4; D3DTA4
UniProt Related Accession #
Q96S38
GenBank Nucleotide #
NM_001136138.1
NCBI Official Full Name
ribosomal protein S6 kinase delta-1 isoform b
NCBI Official Synonym Full Names
ribosomal protein S6 kinase, 52kDa, polypeptide 1
NCBI Official Symbol
RPS6KC1
NCBI Official Synonym Symbols
RPK118; humS6PKh1
UniProt Protein Name
Ribosomal protein S6 kinase delta-1
UniProt Synonym Protein Names
52 kDa ribosomal protein S6 kinase; Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein; SPHK1-binding protein
Protein Family
Ribosomal protein S6 kinase
UniProt Gene Name
RPS6KC1
UniProt Synonym Gene Names
RPK118; S6K-delta-1
UniProt Entry Name
KS6C1_HUMAN
NCBI Protein Information
ribosomal protein S6 kinase delta-1; S6K-delta-1; SPHK1-binding protein; 52 kDa ribosomal protein S6 kinase; ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein

UniProt Comments for RPS6KC1

Function: May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Subunit structure: Interacts with SPHK1 and phosphatidylinositol 3-phosphate. Ref.1

Subcellular location: Cytoplasm. Membrane. Note: Also found in some small dot-like or ring-shaped early endosome structures. Ref.1

Tissue specificity: Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon. Ref.1

Domain: The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.

Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 MIT domain.Contains 2 protein kinase domains.Contains 1 PX (phox homology) domain.

Caution: Instead of Lys-820, Arg-820 is found at the binding site.

Sequence caution: The sequence CAB92850.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on RPS6KC1

1. cloning and characterization of RPK118 as a sphingosine kinase-1-binding protein

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RPS6KC1 antibody

 Reference Product  PubMed Publications
 PRDX3 antibody  >1 publications with RPS6KC1 and PRDX3
 SPHK1 antibody  >1 publications with RPS6KC1 and SPHK1

Diseases associated with anti-RPS6KC1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with RPS6KC1 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with RPS6KC1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-RPS6KC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with RPS6KC1 and Heart
 Liver Antibodies  >1 publications with RPS6KC1 and Liver
 Intestine Antibodies  >1 publications with RPS6KC1 and Intestine
 Kidney Antibodies  >1 publications with RPS6KC1 and Kidney
 Muscle Antibodies  >1 publications with RPS6KC1 and Muscle
 Lung Antibodies  >1 publications with RPS6KC1 and Lung
 Testis Antibodies  >1 publications with RPS6KC1 and Testis
 Brain Antibodies  >1 publications with RPS6KC1 and Brain
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