HVCN1 Antibody – Rabbit Polyclonal

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Function: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. Ref.6

Enzyme regulation: Sensitive to zinc ions and is inhibited by them. Ref.6

Subunit structure: Homodimer. Ref.7

Subcellular location: Membrane; Multi-pass membrane protein. Note: Associates mainly with intracellular compartment membranes. Ref.6 Ref.7

Tissue specificity: Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen. Ref.6

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.The C-terminal coiled coil region mediates homodimerization and is essential for localization.

Sequence similarities: Belongs to the hydrogen channel family.

Sequence caution: The sequence AAQ89413.1 differs from that shown. Reason: Frameshift at positions 164 and 175.